Map2k4^tm1Lizon
Targeted Allele Detail

Summary

• Symbol: Map2k4^tm1Lizon
• Name: mitogen-activated protein kinase kinase 4; targeted mutation 1, Leonard I Zon
• MGI ID: MGI:1861969
• Synonyms: SEK1^-
• Gene: Map2k4 Location: Chr11:65579069-65679123 bp, - strand Genetic Position: Chr11, 40.53 cM
• Alliance: Map2k4^tm1Lizon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48772
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin resistance cassette disrupted two exons encoding part of the catalytic domain of the protein. Western blots of embryonic fibroblasts from homozygous mutant mice showed no detectable protein for the targeted gene. (J:48772)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Map2k4 Mutation: 32 strains or lines available

References

• Original: J:48772 Ganiatsas S, et al., SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6881-6
• All: 2 reference(s)