Cyp1a2^tm1Gonz
Targeted Allele Detail

Summary

• Symbol: Cyp1a2^tm1Gonz
• Name: cytochrome P450, family 1, subfamily a, polypeptide 2; targeted mutation 1, Frank J Gonzalez
• MGI ID: MGI:1861917
• Synonyms: Cyp1a2-, CYP1A2-
• Gene: Cyp1a2 Location: Chr9:57584220-57590938 bp, - strand Genetic Position: Chr9, 31.3 cM
• Alliance: Cyp1a2^tm1Gonz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25724
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into exon 2, which is the first coding exon. Western blot analysis on liver microsomes derived from adult homozygous mice demonstrated that no detectable protein was encoded by this allele. (J:25724)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cyp1a2 Mutation: 36 strains or lines available

References

• Original: J:25724 Pineau T, et al., Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2. Proc Natl Acad Sci U S A. 1995 May 23;92(11):5134-8
• All: 12 reference(s)