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Wo
Transgenic Allele Detail
Summary
Symbol: Wo
Name: wocko
MGI ID: MGI:1861589
Gene: Wo  Location: unknown  Genetic Position: Chr1, Syntenic
Alliance: Wo page
Transgene
origin
Strain of Origin:  (C57BL/6J x DBA/2J)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutations:    Insertion, Other
 
Mutation detailsThe inserted transgenic construct contains a human vasopressin promoter region adjoined to a 1.9 kb fragment of a v-src gene from the Schmidt-Ruppin A strain of RSV. Southern blot analysis indicated that a single copy of the construct integrated into the genome of founder mice. Mapping data indicated that a complex rearrangement involving 6.3 cM of flanking genomic DNA had taken place at the transgene insertion site. The DNA was not deleted nor simply inverted and involved at least 4 breakpoints. (J:62376)
Inheritance:    Dominant
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wo Mutation:  0 strains or lines available
Notes
This transgenic neurological mutation disrupts inner ear development. Mutant mice display a dominant behavioral phenotype of circling, hyperactivity, and head-tossing, like waltzer class mutants. Viability of homozygotes is reduced. Both structural and neural components of the inner ear were disrupted due to aberrant development (J:11245).
References
Original:  J:11245 Crenshaw EB 3rd, et al., Wocko, a neurological mutant generated in a transgenic mouse pedigree. J Neurosci. 1991 Jun;11(6):1524-30
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
09/19/2023
MGI 6.22
The Jackson Laboratory