War
Chemically induced Allele Detail

Summary

• Symbol: War
• Name: warfarin resistance
• MGI ID: MGI:1861144
• Gene: War Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: War page

Mutation origin

• Strain of Origin: PBI

Mutation description

• Allele Type: Chemically induced (other)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any War Mutation: 0 strains or lines available

Notes

Found in a wild population in the Plant Breeding Institute, Cambridge. It was discovered because it occurred in this population on the same chromosome as a closely linked color mutation, extreme dilution (Tyr^c-e), whose frequency was noted to be increasing. Wild-type mice of both sexes were fully susceptible when tested at 4 months of age. Both War/War and War/+ females were fully resistant when tested under the same conditions. Less than 100 per cent of similarly tested War/War males were resistant, and the proportion of resistant War/+ males was intermediate between that and 0 per cent. Modifying genetic factors affected the degree of resistance in males but not in females. A similar mutation for warfarin resistance occurs in the rat and occupies an analogous position linked to the p and Tyr loci in that species (J:5635).

References

• Original: J:220220 Wallace ME, PBI wild strain, warfarin resistant. Mouse News Lett. 1971;45:19
• All: 7 reference(s)