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Targeted Allele Detail
Symbol: Grm2tm1Nak
Name: glutamate receptor, metabotropic 2; targeted mutation 1, Shigetada Nakanishi
MGI ID: MGI:1857988
Synonyms: mGluR2 -
Gene: Grm2  Location: Chr9:106521733-106533308 bp, - strand  Genetic Position: Chr9, 57.98 cM
Alliance: Grm2tm1Nak page
Germline Transmission:  Earliest citation of germline transmission: J:34606
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced the translation initiation site and its downstream sequence in exon 2. Northern blot analysis and western blot analysis confirmed the absence of expression from this allele (data not shown). Immunocytochemical studies did not detect protein in hippocampal coronal sections of homozygous mutant adult mice. (J:34606)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grm2 Mutation:  32 strains or lines available
Original:  J:34606 Yokoi M, et al., Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2. Science. 1996 Aug 2;273(5275):645-7
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory