Grm4^tm1Hpn
Targeted Allele Detail

Summary

• Symbol: Grm4^tm1Hpn
• Name: glutamate receptor, metabotropic 4; targeted mutation 1, David R Hampson
• MGI ID: MGI:1857980
• Synonyms: Gprc1d^tm1Hpn, mGluR4-
• Gene: Grm4 Location: Chr17:27641361-27732800 bp, - strand Genetic Position: Chr17, 14.05 cM
• Alliance: Grm4^tm1Hpn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35793
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into an EcoRV site of an exon that encodes a region encompassing Gly 246-Arg 291 of the putative amino terminal extracellular domain of the protein. Immunoblots of cerebella from homozygous mutant mice showed no detectable protein. (J:35793)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Grm4 Mutation: 44 strains or lines available

References

• Original: J:35793 Pekhletski R, et al., Impaired cerebellar synaptic plasticity and motor performance in mice lacking the mGluR4 subtype of metabotropic glutamate receptor. J Neurosci. 1996 Oct 15;16(20):6364-73
• All: 19 reference(s)