Sod1^tm1Cep
Targeted Allele Detail

Summary

• Symbol: Sod1^tm1Cep
• Name: superoxide dismutase 1, soluble; targeted mutation 1, Cephalon
• MGI ID: MGI:1857872
• Synonyms: SOD1^-
• Gene: Sod1 Location: Chr16:90017650-90023221 bp, + strand Genetic Position: Chr16, 51.56 cM, cytoband B5-C3
• Alliance: Sod1^tm1Cep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33472
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced the entire coding region and sequences immediately 5' of exon 1. Immunoblot and enzyme activity analyses did not detect protein in red blood cells from homozygous mutant mice. (J:33472)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sod1 Mutation: 37 strains or lines available

References

• Original: J:33472 Reaume AG, et al., Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nat Genet. 1996 May;13(1):43-7
• All: 27 reference(s)