Pla2g2a^Mom1-s
Spontaneous Allele Detail

Summary

• Symbol: Pla2g2a^Mom1-s
• Name: phospholipase A2, group IIA (platelets, synovial fluid); modifier of Min1, tumor susceptibility
• MGI ID: MGI:1857821
• Synonyms: IIA sPLA2, Mom-1, sPLA2 IIa, sPLA2-IIA^-
• Gene: Pla2g2a Location: Chr4:138559171-138562497 bp, + strand Genetic Position: Chr4, 70.57 cM
• Alliance: Pla2g2a^Mom1-s page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of thymidine at position 208 (position 166 from the ATG) results in a frameshift that creates a stop codon 13 amino acids downstream in exon 4. The mutation causes the loss of a BamHI restriction site and a defective protein. (J:26137, J:28799)
• Inheritance: Dominant

Tumor Data

List all tumor models in MMHCdb carrying Pla2g2a^Mom1-s

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pla2g2a Mutation: 8 strains or lines available

Notes

129 substrains, C57BL/6J and BTBR carry this inbred strain variant allele.

A mutation in the Apc gene of the mouse causes multiple intestinal adenomas in the C57BL/6J strain on which it arose. In crosses with other strains, the number of tumors is reduced. A locus controlling about 50% of genetic variation in tumor number has been identified as Pla2g2a.

References

• Original: J:15703 Dietrich WF, et al., Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell. 1993 Nov 19;75(4):631-9
• All: 38 reference(s)