Nox3^het-2J
Spontaneous Allele Detail

Summary

• Symbol: Nox3^het-2J
• Name: NADPH oxidase 3; head tilt 2 Jackson
• MGI ID: MGI:1857794
• Gene: Nox3 Location: Chr17:3685515-3746536 bp, - strand Genetic Position: Chr17, 2.05 cM
• Alliance: Nox3^het-2J page

Mutation origin

• Strain of Origin: B10.Q-H2^q/SgJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: The mutation in the het-2J mouse was identified as a G-to-A substitution at coding nucleotide position 1222 (c.1222G>A), replacing a glycine residue with an arginine at position 408 (p.G408R). The glycine residue is highly conserved and is part of an NADPH binding site. (J:89010)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nox3 Mutation: 40 strains or lines available

Notes

The head-leaning and circling are more dramatic than the original het mutation. However, ABR (auditory-evoked brainstem response) testing of three 5-week old homozygotes and heterozygotes showed normal hearing indistinquishable from wild-type controls and the original het/het mutants. Viability and fertility of both sexes of mice are normal; although trampling of pups is common(J:56803).

References

• Original: J:56803 Cook S, The Jackson Laboratory Mouse Mutant Resource 1999 Mutation Reports. MGI Direct Data Submission. 1999
• All: 2 reference(s)