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Mesp1tm1Ysa
Targeted Allele Detail
Summary
Symbol: Mesp1tm1Ysa
Name: mesoderm posterior 1; targeted mutation 1, Yumiko Saga
MGI ID: MGI:1857785
Synonyms: Mesp1-beta-gal, Mesp1lacZ
Gene: Mesp1  Location: Chr7:79441989-79443338 bp, - strand  Genetic Position: Chr7, 45.16 cM
Alliance: Mesp1tm1Ysa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55840
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA lacZ reporter gene and pgk-neo cassette were ligated in frame at a NcoI site located at the translational initiation site of the gene, creating a knock-in vector that initiated lacZ translation at the same initiation site as the coding sequence of the gene. (J:55840)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 101 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mesp1 Mutation:  18 strains or lines available
References
Original:  J:55840 Saga Y, et al., MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube. Development. 1999 Aug;126(15):3437-47
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
09/24/2024
MGI 6.24
The Jackson Laboratory