Syt1^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Syt1^tm1Sud
• Name: synaptotagmin I; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:1857252
• Synonyms: Syt-
• Gene: Syt1 Location: Chr10:108333511-108846843 bp, - strand Genetic Position: Chr10, 56.52 cM
• Alliance: Syt1^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21602
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 5' portion of the exon encoding amino acids 270 through 308 and the preceding intron were replaced with a neomycin selection cassette. In addition to the coding sequence, the intron acceptor site was deleted. Lysates derived from the brains of homozygous mice were shown to contain less than 5% of the amount of a truncated form of the encoded protein compared to controls by immunoblotting. (J:21602)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Syt1 Mutation: 39 strains or lines available

References

• Original: J:21602 Geppert M, et al., Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse. Cell. 1994 Nov 18;79(4):717-27
• All: 41 reference(s)