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Targeted Allele Detail
Symbol: Prkcgtm1Stl
Name: protein kinase C, gamma; targeted mutation 1, Susumu Tonegawa
MGI ID: MGI:1857237
Synonyms: PKCgamma-KO
Gene: Prkcg  Location: Chr7:3351982-3379615 bp, + strand  Genetic Position: Chr7, 1.93 cM
Alliance: Prkcgtm1Stl page
Germline Transmission:  Earliest citation of germline transmission: J:16392
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced 2.5kb of sequence containing the exon that encodes the nucleotide binding domain. Northern blot analysis of total brain RNA demonstrated that homozygous mutant mice lack normal transcripts. Western blot analysis of total brain protein did not detect the protein in homozygous mutant mice. (J:16392)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkcg Mutation:  27 strains or lines available
Original:  J:16392 Abeliovich A, et al., Modified hippocampal long-term potentiation in PKC gamma-mutant mice. Cell. 1993 Dec 31;75(7):1253-62
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
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