mut1
Chemically induced Allele Detail

Summary

• Symbol: mut1
• Name: mutator 1
• MGI ID: MGI:1856962
• Gene: mut1 Location: unknown
• Alliance: mut1 page

Mutation origin

• Strain of Origin: 101/H

Mutation description

• Allele Type: Chemically induced (other)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any mut1 Mutation: 0 strains or lines available

Notes

Induced by thiophosphamide (thio-TEPA, thio-TEPA). Inbred lines differ in sensitivity to the chemical mutagen thiophosphamide based on the frequencies of chromosomal aberrations found in bone marrow cells after TEPA treament. The 101/H and C57BL/6J strains were among those with greater sensitivity, while C3H/Sn and CBA/Lac were relatively insensitive. Cytogenetic effects of TEPA on bone marrow cell chromosomes from backcrosses of sensitive with nonsensitive lines were studied, using (C3H x 101)F1 x 101 and (CBA x C57BL/6)F1 x C57BL/6 backcrosses. Two classes of progeny differing significantly in frequency of cells with aberrations were found in each backcross. Results were interpreted to indicate the occurrence of a mut1 in the 101 strain and a mut2 mutation in C57BL/6, each increasing the frequency of aberrations caused by TEPA treatment (J:4476).

References

• Original: J:4476 Surkova NI, et al., [Genetic control of mutability in laboratory mice. I. Genetic analysis of the sensitivity of mice of strains 101/H and C57BL/6 to the mutagenic effect of thio-TEPA]. Genetika. 1977;13(9):1572-8
• All: 1 reference(s)