lop2
Spontaneous Allele Detail

Summary

• Symbol: lop2
• Name: lens opacity 2
• MGI ID: MGI:1856941
• Gene: lop2 Location: unknown
• Alliance: lop2 page

Mutation origin

• Strain of Origin: 101/H x 129P3/J

Mutation description

• Allele Type: Spontaneous
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any lop2 Mutation: 0 strains or lines available

Notes

Mice of the 101/H inbred strain are homozygous for this allele, which causes a colored cataract revealed by examination with a slit lamp. The cataract is present by weaning age. The 129X1/Sv strain is related to 101/H and also probably carries this allele, while C3H/He, C57BL/Ola, C57BL/10, DBA/2, JU/Fa, and 101/El do not. Several sublines of CBA/Ca have a bright white cataract which appears to be controlled by a single semidominant gene tentatively designated Lop3. F1 mice of crosses to C3H/He have very mild cataracts. However, crosses between CBA/Ca and 101/H to determine whether lop2 and Lop3 are alleles gave ambiguous results. Neither lop2 nor Lop3 is allelic with the original lens opacity gene Cat^Lop (formerly Mip). No tests for allelism with any of the numerous other genes causing cataracts in mice have been made (J:8092).

References

• Original: J:8092 West JD, et al., Inherited cataracts in inbred mice. Genet Res. 1985 Aug;46(1):45-56
• All: 1 reference(s)