Hsdr1
Radiation induced Allele Detail

Summary

• Symbol: Hsdr1
• Name: hepatocyte specific developmental regulation 1
• MGI ID: MGI:1856906
• Synonyms: albino lethal factor, alf
• Gene: Hsdr1 Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: Hsdr1 page

Mutation origin

• Strain of Origin: STOCK Del(7)Tyr^c-3H and Tyr^c-14CoS

Mutation description

• Allele Type: Radiation induced
• Mutation: Deletion
• Hsdr1 involves 1 genes/genome features (Hsdr1) View all
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsdr1 Mutation: 0 strains or lines available

Notes

A number of radiation-induced deletions overlap at the albino (Tyr, tyrosinase) locus. References J:5437 and J:6158 describe the albino deletions that identified Hsdr1, Del(7)Tyr and Tyr. The proximal breakpoint of the Tyr^c-14Cos, deletion disrupts the gene Fah, encoding the enzyme fumarylacetoacetate hydrolase (EC 3.7.1.2) (J:2947), and it has been argued that the lethal effect of the deletion may result from this disruption, and that Hsdr1 and Fah are identical (J:16987).

References

• Original: J:10522 Ruppert S, et al., Two genetically defined trans-acting loci coordinately regulate overlapping sets of liver-specific genes. Cell. 1990 Jun 1;61(5):895-904
• All: 8 reference(s)