Lmf1^cld
Spontaneous Allele Detail

Summary

• Symbol: Lmf1^cld
• Name: lipase maturation factor 1; combined lipase deficiency
• MGI ID: MGI:1856820
• Synonyms: cld
• Gene: Lmf1 Location: Chr17:25798059-25881800 bp, + strand Genetic Position: Chr17, 12.7 cM, cytoband A3.3
• Alliance: Lmf1^cld page

Mutation origin

• Strain of Origin: M. m. musculus (Northern Jutland, Denmark)

Mutation description

• Allele Type: Spontaneous
• Mutation: Viral insertion
• Mutation details: This mutation was found as a "parasitic lethal" in t^w73 and recovered from the haplotype by recombination. A full-length murine endogenous retrovirus (MuERV) is inserted into intron 7. This results in the expression of an aberrant mRNA that contains sequences derived from exons 1-7, but is missing sequences derived from exons 8-11. 400 bp of viral sequence replaced the missing sequences in the mRNA. (J:115044, J:130178)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lmf1 Mutation: 30 strains or lines available

Notes

Lmf1 t^w73lab is one of three spontaneous, recessive, lethal mutations found in a wild-derived t haplotype. The other mutations are t^w73 and t^w73lab.

References

• Original: J:7083 Paterniti JR Jr, et al., Combined lipase deficiency (cld): a lethal mutation on chromosome 17 of the mouse. Science. 1983 Jul 8;221(4606):167-9
• All: 11 reference(s)