Nkx6-1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:279716 Braitsch CM, et al., LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:8351682
Gene symbol:	Nkx6-1
Gene name:	NK6 homeobox 1

Antibody:	Anti-Nkx6.1 (clone F64A6B4)
Detection system:	Secondary antibody coupled to Alexa Fluor

Results

S3C WT lower ©

Specimen S3C WT: embryonic day 12.0 (more

)
Note: Controls were either wild type or heterozygous littermates.

Structure	Level	Pattern	Image	Note
TS20: pancreas epithelium	Present		S3C WT lower

Specimen S3C Lats1/2^PanKO: embryonic day 12.0; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS20: pancreas epithelium	Present		S3C Lats1/2^PanKO lower

S3E WT ©

Specimen S3E WT: embryonic day 14.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: green - Nkx6-1; magenta - Ctnnb1 (assay MGI:8351284).

Structure	Level	Pattern	Image	Note
TS22: pancreas epithelium	Present	Non-Uniform	S3E WT	A slight enrichment of NKX6-1 within the central bipotent (ductal and endocrine progenitor) compartment was seen at E14.5.

Specimen S3E Lats1/2^PanKO: embryonic day 14.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: green - Nkx6-1; magenta - Ctnnb1 (assay MGI:8351284).

Structure	Level	Pattern	Image	Note
TS22: pancreas epithelium	Ambiguous		S3E Lats1/2^PanKO	Expression was decreased in Lats1/2<PanKO> pancreas.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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