Acta2 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:279716 Braitsch CM, et al., LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:8351283
Gene symbol:	Acta2
Gene name:	actin alpha 2, smooth muscle, aorta

Antibody:	Anti-smooth muscle alpha-Actin (clone 1A4)
Detection system:	Secondary antibody coupled to Alexa Fluor

Results

2F ©

Specimen 2F: embryonic day 14.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: green - Acta2; magenta - Ctnnb1 (assay MGI:8351284).

Structure	Level	Pattern	Image	Note
TS22: pancreas epithelium	Absent		2F

2J ©

Specimen 2J: embryonic day 14.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: green - Acta2; magenta - Ctnnb1 (assay MGI:8351284).

Structure	Level	Pattern	Image	Note
TS22: pancreas	Present	Non-Uniform	2J	Lats1/2<PanKO> mutant cells lost many epithelial characteristics and increasingly expressed aberrant Acta2.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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