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Gene Expression Data
Assay Details
Assay
Reference: J:290119 Soleilhavoup C, et al., Nolz1 expression is required in dopaminergic axon guidance and striatal innervation. Nat Commun. 2020 Jun 19;11(1):3111
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8270718
Gene symbol: Otx2
Gene name: orthodenticle homeobox 2
Antibody: Anti-Otx2 (AF1979)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Assay notes: Nolz1-/- mutant embryos, in which the coding region of Nolz1 has been replaced by beta-Galactosidase (also referred to as Nolz1<bgal/bgal>). Zfp503<tm1.1Bpb> (neo cassette removed) has been used in the annotations, but it could be Zfp503<tm1Bpb> (neo cassette still present).
Results
Specimen S1c WT: embryonic day 18.5 (more )
Note: Double labeled: green - Otx2; red - Th (assay MGI:8270443).
Structure Cell Type Level Pattern Image Note
TS26: midbrain midbrain dopaminergic neuron Present S1c WT Otx2 TH
Specimen S1c Nolz1bGal/bGal: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Otx2; red - Th (assay MGI:8270443).
Structure Cell Type Level Pattern Image Note
TS26: midbrain midbrain dopaminergic neuron Present S1c Nolz1bgal/bgal Otx2 TH
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/06/2026
MGI 6.29 		The Jackson Laboratory