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Gene Expression Data
Assay Details
Assay
Reference: J:290119 Soleilhavoup C, et al., Nolz1 expression is required in dopaminergic axon guidance and striatal innervation. Nat Commun. 2020 Jun 19;11(1):3111
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8270623
Gene symbol: Bcl11b
Gene name: B cell leukemia/lymphoma 11B
Antibody: anti-CTIP2 [25B6] (ab18465)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Assay notes: Nolz1-/- mutant embryos, in which the coding region of Nolz1 has been replaced by beta-Galactosidase (also referred to as Nolz1<bgal/bgal>). Zfp503<tm1.1Bpb> (neo cassette removed) has been used in the annotations, but it could be Zfp503<tm1Bpb> (neo cassette still present).
Results
Specimen 2c: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503+ (more )
Note: Double labeled: green - Bcl11b; red - Ppp1r1b (assay MGI:8270622).
Structure Cell Type Level Pattern Image Note
TS26: corpus striatum striatum neuron Present Regionally restricted 2c' , 2c Expression is detected in striatal projection neurons and overlaps with Ppp1r1b staining.
Specimen 2d: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Bcl11b; red - Ppp1r1b (assay MGI:8270622).
Structure Cell Type Level Pattern Image Note
TS26: corpus striatum striatum neuron Present Regionally restricted 2d' , 2d Expression is detected in striatal projection neurons normally in the mutant. Staining does not overlap with Ppp1r1b staining, which appears in clusters of abnormally fasciculated axons.
Specimen 2g: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503+ (more )
Note: Rostral striatum. Double labeled: green - Bcl11b; red - Zfp503 reporter (assay MGI:8270491).
Structure Cell Type Level Pattern Image Note
TS26: corpus striatum striatum neuron Present Regionally restricted 2g , 2g' Expression is detected in striatal projection neurons and overlaps with beta-galactosidase reporter staining.
Specimen 2h: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503+ (more )
Note: Caudal striatum. Double labeled: green - Bcl11b; red - Zfp503 reporter (assay MGI:8270491).
Structure Cell Type Level Pattern Image Note
TS26: corpus striatum striatum neuron Present Regionally restricted 2h' , 2h Expression is detected in striatal projection neurons and overlaps with beta-galactosidase reporter staining.
Specimen 2i: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Rostral striatum. Double labeled: green - Bcl11b; red - Zfp503 reporter (assay MGI:8270491).
Structure Cell Type Level Pattern Image Note
TS26: corpus striatum striatum neuron Present Regionally restricted 2i' , 2i Expression is detected in striatal projection neurons normally in the mutant and overlaps with beta-galactosidase reporter staining.
Specimen 2j: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Caudal striatum. Double labeled: green - Bcl11b; red - Zfp503 reporter (assay MGI:8270491).
Structure Cell Type Level Pattern Image Note
TS26: corpus striatum striatum neuron Present Regionally restricted 2j , 2j' Expression is detected in striatal projection neurons normally in the mutant and overlaps with beta-galactosidase reporter staining.
Specimen S2b Nolz1bgal/+: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503+ (more )
Note: Double labeled: green - Bcl11b; red - Nkx2-1 (assay MGI:8272302).
Structure Level Pattern Image Note
TS26: globus pallidus Present S2b Nolz1bgal/+ top
Specimen S2b Nolz1bgal/bgal: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Bcl11b; red - Nkx2-1 (assay MGI:8272302).
Structure Level Pattern Image Note
TS26: globus pallidus Present S2b Nolz1bgal/bgal top Expression in the globus pallidus was normal in the Nolz1<bgal/bgal> embryo.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/06/2026
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