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Gene Expression Data
Assay Details
Assay
Reference: J:176499 Rederstorff M, et al., Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy. PLoS One. 2011;6(8):e23094
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8213488
Gene symbol: Cacna1s
Gene name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Antibody: anti-DHPR (MAB427)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 3C DHPR +/+ upper: postnatal month 2 (more )
Note: Double labeled: green - Cacna1s; red - Ryr1 (assay MGI:8213489).
Structure Level Pattern Image Note
TS28: quadriceps femoris muscle Present 3C +/+ DPHR upper , 3C +/+ Overlay upper , 3C +/+ inset upper
Specimen 3C DHPR -/- upper: postnatal month 2; Selenontm1.2Mred/Selenontm1.2Mred (more )
Note: Double labeled: green - Cacna1s; red - Ryr1 (assay MGI:8213489).
Structure Level Pattern Image Note
TS28: quadriceps femoris muscle Present Regionally restricted 3C -/- inset upper , 3C -/- DPHR upper , 3C -/- Overlay upper Authors report normal intracellular distribution and colocalization of expression at trial sites.
Specimen 3C DHPR +/+ lower: postnatal month 2 (more )
Note: Double labeled: green - Cacna1s; red - Ryr3 (assay MGI:8213490).
Structure Level Pattern Image Note
TS28: quadriceps femoris muscle Present 3C +/+ Overlay lower , 3C +/+ inset lower , 3C +/+ DPHR lower
Specimen 3C DHPR -/- lower: postnatal month 2; Selenontm1.2Mred/Selenontm1.2Mred (more )
Note: Double labeled: green - Cacna1s; red - Ryr3 (assay MGI:8213490).
Structure Level Pattern Image Note
TS28: quadriceps femoris muscle Present Regionally restricted 3C -/- Overlay lower , 3C -/- inset lower , 3C -/- DPHR lower Authors report normal intracellular distribution and colocalization of expression at trial sites.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/06/2026
MGI 6.29 		The Jackson Laboratory