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Gene Expression Data
Assay Details
Assay
Reference: J:306107 Niborski LL, et al., Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model. Dis Model Mech. 2021 May 1;14(5):dmm047498
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8187728
Gene symbol: Lama1
Gene name: laminin, alpha 1
Antibody: anti-laminin (L9393)
Assay notes: Embryos and postnatal kidneys up to 2 months of age were fixed with 60% ethanol/11% formaldehyde and 10% acetic acid.
Results
Specimen 5J: embryonic day 15.5 (more )
Note: Double labeled: red - Lama1; green - Muc1 (assay MGI:8187727).
Structure Level Pattern Image Note
TS23: metanephros Present Regionally restricted 5J Expression in basement membranes.
Specimen 5K: embryonic day 15.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Note: Double labeled: red - Lama1; green - Muc1 (assay MGI:8187727).
Structure Level Pattern Image Note
TS23: metanephros Weak Regionally restricted 5K Global decrease in expression. Partially disorganized pattern compared to wild type.
Specimen 5L: embryonic day 15.5 (more )
Note: Double labeled: green - Lama1; red - Tjp1 (assay MGI:8187729).
Structure Level Pattern Image Note
TS23: metanephros Present Regionally restricted 5L Expression in basement membranes.
Specimen 5M: embryonic day 15.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Note: Double labeled: green - Lama1; red - Tjp1 (assay MGI:8187729).
Structure Level Pattern Image Note
TS23: metanephros Weak Regionally restricted 5M Global decrease in expression. Partially disorganized pattern compared to wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory