About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:359864 Chen Y, et al., The Ednrb-Aim2-AKT axis regulates neural crest-derived melanoblast proliferation during early development. Development. 2024 Nov 15;151(22):dev202444
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7861730
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved caspase-3 (Asp175) (5A1E; #9664)
Detection system: Secondary antibody
Results
Specimen 2A Ednrb-/+ upper CC: embryonic day 11.5; Ednrbtm1Myks/Ednrb+ (more )
Note: Double labeled: red - Casp3; green - Pmel (assay MGI:7861728).
Structure Cell Type Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest melanoblast Trace 2A -/+ upper merged , 2A -/+ upper CC3 , 2A Ednrb-/+ upper Almost no apoptotic melanoblasts in both control and Ednrb-/- embryos.
Specimen 2A Ednrb-/- upper CC: embryonic day 11.5; Ednrbtm1Myks/Ednrbtm1Myks (more )
Note: Double labeled: red - Casp3; green - Pmel (assay MGI:7861728).
Structure Cell Type Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest melanoblast Trace 2A -/- upper merged , 2A Ednrb-/- upper , 2A -/- upper CC3 No difference in number of expressing melanoblasts compared to control embryos.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory