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Gene Expression Data
Assay Details
Assay
Reference: J:354443 Zhang B, et al., SMC3 contributes to heart development by regulating super-enhancer associated genes. Exp Mol Med. 2024 Aug;56(8):1826-1842
Assay type: RNA in situ
MGI Accession ID: MGI:7861276
Gene symbol: Ets2
Gene name: E26 avian leukemia oncogene 2, 3' domain
Probe: Mm-Ets2 (1123591)
Probe preparation: Antisense
Visualized with: Fluorescence
Assay notes: RNAscope probe. Amplification channel C2.
Results
Specimen 5a E10.5 WT: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: heart Present Ubiquitous 5a E10.5 WT Ets2 , 5a E10.5 WT DAPI;Ets2
Specimen 5a P0 WT: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: heart Present Ubiquitous 5a P0 WT Ets2 , 5a P0 WT DAPI;Ets2
Specimen 6a Smc3fl/fl: embryonic day 10.5; Smc3em1Smoc/Smc3em1Smoc (more )
Note: Double labeled: red - Ets2; orange - Smc3 (assay MGI:7861270).
Structure Level Pattern Image Note
TS17: heart Present 6a Smc3fl/fl ii , 6a Smc3fl/fl top , 6a Smc3fl/fl i
Specimen 6a Smc3fl/fl; Nkx2.5-Cre: embryonic day 10.5; Nkx2-5em2(icre)Gpt/Nkx2-5+, Smc3em1Smoc/Smc3em1Smoc (more )
Note: Conditional mutant. Double labeled: red - Ets2; orange - Smc3 (assay MGI:7861270).
Structure Level Pattern Image Note
TS17: heart Weak 6a Smc3fl/fl;Nkx2.5-Cre ii , 6a Smc3fl/fl;Nkx2.5-Cre i , 6a Smc3fl/fl;Nkx2.5-Cre top A notable reduction in the fluorescence intensity was observed across all regions of the heart in the Smc3<fl/fl>; Nkx2.5-Cre embryos compared with control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory