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Gene Expression Data
Assay Details
Assay
Reference: J:297650 Roeseler DA, et al., Gbx2 is required for the migration and survival of a subpopulation of trigeminal cranial neural crest cells. J Dev Biol. 2020;8(33)
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7840267
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved caspase-3
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 5C/E: embryonic day 9.5 (more )
Note: Genetic background of specimen was either wild type or heterozygous. Double labeled: green - Casp3; red - Tfap2a (assay MGI:7840266).
Structure Level Pattern Image Note
TS15: head mesenchyme Present Regionally restricted 5C , 5E Expression in cells in mesenchyme medial to trigeminal ganglion.
Specimen 5D/F: embryonic day 9.5 (more )
Note: Double labeled: green - Casp3; red - Tfap2a (assay MGI:7840266).
Structure Level Pattern Image Note
TS15: head mesenchyme Present Regionally restricted 5D , 5F Expression in cells in mesenchyme medial to trigeminal ganglion.
Specimen 5I/K: embryonic day 9.5; Gbx2tm1Mrt/Gbx2tm1Mrt (more )
Note: Genetic background of specimen was either wild type or heterozygous. Double labeled: green - Casp3; red - Tfap2a (assay MGI:7840266).
Structure Level Pattern Image Note
TS15: head mesenchyme Present Regionally restricted 5K , 5I Expression in cells in mesenchyme medial to trigeminal ganglion.
TS15: migrating neural crest Present Regionally restricted 5I , 5K Significantly increased expression in stream of cranial neural crest cells migrating into trigeminal ganglion and in surrounding mesenchyme compared to wild type.
Specimen 5J/L: embryonic day 9.5; Gbx2tm1Mrt/Gbx2tm1Mrt (more )
Note: Double labeled: green - Casp3; red - Tfap2a (assay MGI:7840266).
Structure Level Pattern Image Note
TS15: head mesenchyme Present Regionally restricted 5J , 5L Expression in cells in mesenchyme medial to trigeminal ganglion.
TS15: migrating neural crest Present Regionally restricted 5L , 5J Significantly increased expression in stream of cranial neural crest cells migrating into trigeminal ganglion and in surrounding mesenchyme compared to wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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