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Gene Expression Data
Assay Details
Assay
Reference: J:84852 Imanaka-Yoshida K, et al., The dynamic expression of tenascin-C and tenascin-X during early heart development in the mouse. Differentiation. 2003 Jun;71(4-5):291-8
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7645230
Gene symbol: Tnc
Gene name: tenascin C
Reporter: lacZ
Direct Detection
Results
Specimen 1A E7.5: embryonic day 7.5; Tnctm1Sia/Tnc+ (more )
Structure Level Pattern Image Note
TS11: cardiogenic plate Present 1A E7.5 Expression in heart forming crescent in presomite stage embryo.
Specimen 1A E8.0: embryonic day 8.0; Tnctm1Sia/Tnc+ (more )
Structure Level Pattern Image Note
TS12: primitive heart tube Present Regionally restricted 1A E8.0 When bilateral heart primordia fuse to form a single heart tube, expression limited to caudal part of heart.
Specimen 1A E8.5: embryonic day 8.5; Tnctm1Sia/Tnc+ (more )
Structure Level Pattern Image Note
TS13: heart Present Regionally restricted 1A E8.5 When bilateral heart primordia fuse to form a single heart tube, expression limited to caudal part of heart.
Specimen 1B: embryonic day 7.5; Tnctm1Sia/Tnc+ (more )
Structure Cell Type Level Pattern Image Note
TS11: intraembryonic coelom mesodermal cell Present Regionally restricted 1B Transient expression in mesodermal cells forming pericardial coelom.
TS11: embryo endoderm Absent 1B No expression in endoderm.
Specimen 1C: embryonic day 7.5; Tnctm1Sia/Tnc+ (more )
Structure Cell Type Level Pattern Image Note
TS11: intraembryonic coelom mesodermal cell Present Regionally restricted 1C Transient expression in mesodermal cells forming pericardial coelom.
TS11: embryo endoderm Absent 1C No expression in endoderm.
Specimen 2A: embryonic day 9.5; Tnctm1Sia/Tnc+ (more )
Structure Level Pattern Image Note
TS15: outflow tract Present 2A
Specimen 2B: embryonic day 9.5; Tnctm1Sia/Tnc+ (more )
Structure Level Pattern Image Note
TS15: outflow tract Present 2B
Specimen 2C: embryonic day 9.5; Tnctm1Sia/Tnc+ (more )
Note: Double labeled: blue - Tnc reporter; brown - Tnc protein (assay MGI:7645232).
Structure Cell Type Level Pattern Image Note
TS15: heart fetal cardiomyocyte Present 2C
Specimen 2D: embryonic day 9.5; Tnctm1Sia/Tnc+ (more )
Note: Double labeled: blue - Tnc reporter; brown - Tnc protein (assay MGI:7645232).
Structure Cell Type Level Pattern Image Note
TS15: outflow tract endocardial cushion fetal cardiomyocyte Present Regionally restricted 2D In conotruncal cushion, expression in cardiomyocytes.
TS15: outflow tract endocardial tube endocardial cell Present Regionally restricted 2D Expression in endocardial cells lining endothelium.
TS15: outflow tract cardiac jelly endocardial cell Present Regionally restricted 2D Expression in endocardial cells migrating into cardiac jelly of outflow tract.
Specimen 2E: embryonic day 9.5; Tnctm1Sia/Tnc+ (more )
Note: Double labeled: blue - Tnc; brown - sarcomeric myosin.
Structure Cell Type Level Pattern Image Note
TS15: outflow tract endocardial cushion fetal cardiomyocyte Present Regionally restricted 2E Expression in cardiomyocytes also expressing sarcomeric myosin.
Specimen 2F: embryonic day 9.5; Tnctm1Sia/Tnc+ (more )
Note: Double labeled: blue - Tnc reporter; brown - Tnc protein (assay MGI:7645232).
Structure Cell Type Level Pattern Image Note
TS15: atrioventricular canal endocardial lining endocardial cell Present Regionally restricted 2F Expression in endocardial cells lining endothelium.
TS15: atrioventricular canal endocardial cell Present Regionally restricted 2F Expression in endocardial cells migrating into cardiac jelly of endocardial canal.
Specimen 2I: embryonic day 9.5; Tnctm1Sia/Tnc+ (more )
Note: Double labeled: blue - Tnc reporter; brown - Tnc protein (assay MGI:7645232).
Structure Cell Type Level Pattern Image Note
TS15: pericardium cardiac mesenchymal cell Present Regionally restricted 2I Expression in mesenchymal cells in proepicardial organs and pericardium.
TS15: proepicardium cardiac mesenchymal cell Present Regionally restricted 2I Expression in mesenchymal cells in proepicardial organs and pericardium.
TS15: visceral pericardium mesothelial cell of epicardium Present Regionally restricted 2I No expression in epicardial cells.
TS15: primitive ventricle cardiac muscle fetal cardiomyocyte Present Regionally restricted 2I No expression in ventricular cardiomyocytes.
Specimen 4A: embryonic day 11.5; Tnctm1Sia/Tnc+ (more )
Note: Double labeled: blue - Tnc reporter; brown - Tnc protein (assay MGI:7645232).
Structure Level Pattern Image Note
TS19: visceral pericardium Present 4A
Specimen 4B: embryonic day 11.5; Tnctm1Sia/Tnctm1Sia (more )
Note: Double labeled: blue - Tnc reporter; brown - Tnc protein (assay MGI:7645232).
Structure Level Pattern Image Note
TS19: visceral pericardium Present 4B Expression pattern is same as that of heterozygous embryos.
Specimen 4C: embryonic day 11.5; Tnctm1Sia/Tnc+ (more )
Note: Double labeled: blue - Tnc reporter; brown - Tnxb (assay MGI:7645233).
Structure Level Pattern Image Note
TS19: visceral pericardium Present 4C
Specimen 4D: embryonic day 11.5; Tnctm1Sia/Tnctm1Sia (more )
Note: Double labeled: blue - Tnc reporter; brown - Tnxb (assay MGI:7645233).
Structure Level Pattern Image Note
TS19: visceral pericardium Present 4D Expression pattern is same as that of heterozygous embryos.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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07/29/2025
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