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Gene Expression Data
Assay Details
Assay
Reference: J:342153 Bisia AM, et al., A degron-based approach to manipulate Eomes functions in the context of the developing mouse embryo. Proc Natl Acad Sci U S A. 2023 Oct 31;120(44):e2311946120
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7627452
Gene symbol: Otx2
Gene name: orthodenticle homeobox 2
Antibody: Anti-Otx2 (AF1979)
Detection system: Secondary antibody coupled to Alexa Fluor 594
Results
Specimen S2A control: embryonic day 5.5 (more )
Note: Double labeled: red - Otx2; green - Eomes (assay MGI:7627451).
Structure Level Pattern Image Note
TS7: embryonic visceral endoderm Present S2A Control merge , S2A Control Otx2
TS7: epiblast Present S2A Control merge , S2A Control Otx2
Specimen S2A Null: embryonic day 5.5; Eomestm1.1Rob/Eomestm1.1Rob (more )
Note: Double labeled: red - Otx2; green - Eomes (assay MGI:7627451).
Structure Level Pattern Image Note
TS7: epiblast Present S2A Null merge , S2A Null Otx2 Reduced positive epiblast which failed to proliferate due to the absence of a functional extraembryonic ectoderm.
TS7: embryonic visceral endoderm Absent S2A Null Otx2 , S2A Null merge
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/06/2026
MGI 6.24 		The Jackson Laboratory