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Gene Expression Data
Assay Details
Assay
Reference: J:192361 Srinivasan K, et al., A network of genetic repression and derepression specifies projection fates in the developing neocortex. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19071-8
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7620290
Gene symbol: Bcl11b
Gene name: B cell leukemia/lymphoma 11B
Antibody: anti-Ctip2
Results
Specimen 3A: postnatal (more )
Structure Cell Type Level Pattern Image Note
TS28: cortical layer V cerebral cortex neuron Strong 3A
TS28: cortical layer VI cerebral cortex neuron Moderate 3A
TS28: cortical layer II cerebral cortex neuron Trace 3A Expression was largely absent from the upper layers (2-4).
TS28: cortical layer III cerebral cortex neuron Trace 3A Expression was largely absent from the upper layers (2-4).
TS28: cortical layer IV cerebral cortex neuron Trace 3A Expression was largely absent from the upper layers (2-4).
Specimen 3B: postnatal; Fezf2tm1Skm/Fezf2tm1Skm (more )
Structure Cell Type Level Pattern Image Note
TS28: cortical layer V cerebral cortex neuron Weak 3B Mutant showed a severe reduction of expression.
TS28: cortical layer VI cerebral cortex neuron Present 3B Expression in layer 6 was increased in the mutant.
Specimen 3C: postnatal; Emx1tm1(cre)Krj/Emx1+, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: cortical layer II cerebral cortex neuron Present 3C The conditional mutant showed increased expression in layer 5, 6, and the upper layers.
TS28: cortical layer III cerebral cortex neuron Present 3C The conditional mutant showed increased expression in layer 5, 6, and the upper layers.
TS28: cortical layer IV cerebral cortex neuron Present 3C The conditional mutant showed increased expression in layer 5, 6, and the upper layers.
TS28: cortical layer V cerebral cortex neuron Present 3C The conditional mutant showed increased expression in layer 5, 6, and the upper layers.
TS28: cortical layer VI cerebral cortex neuron Present 3C The conditional mutant showed increased expression in layer 5, 6, and the upper layers.
Specimen 3D: postnatal; Emx1tm1(cre)Krj/Emx1+, Fezf2tm1Skm/Fezf2tm1Skm, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: cortical layer V cerebral cortex neuron Strong 3D Expression was rescued in layer 5 of the double mutant.
Specimen 5E: postnatal day 4; Fezf2tm1Skm/Fezf2tm1Skm (more )
Note: Double labeled: red - Bcl11b; green - Tbr1 (assay MGI:7620298).
Structure Cell Type Level Pattern Image Note
TS28: cortical layer V cerebral cortex neuron Weak 5E Expression was decreased in layer 5 of the mutant.
Specimen 5F: postnatal day 4; Emx1tm1(cre)Krj/Emx1+, Fezf2tm1Skm/Fezf2tm1Skm, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant. Double labeled: red - Bcl11b; green - Tbr1 (assay MGI:7620298).
Structure Cell Type Level Pattern Image Note
TS28: cortical layer V cerebral cortex neuron Present 5F Expression level was restored to control levels in this mutant.
Specimen 7K: postnatal day 0; Satb2tm1Rug/Satb2+ (more )
Note: Double labeled: red - Bcl11b; green - Auts2 (assay MGI:7620362).
Structure Level Pattern Image Note
TS27: neocortex layer Present 7K
Specimen 7M: postnatal day 0; Satb2tm1Rug/Satb2tm1Rug (more )
Note: Double labeled: red - Bcl11b; green - Auts2 (assay MGI:7620362).
Structure Level Pattern Image Note
TS27: neocortex layer Present 7M
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory