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Gene Expression Data
Assay Details
Assay
Reference: J:293624 Lee S, et al., Cleft lip and cleft palate in Esrp1 knockout mice is associated with alterations in epithelial-mesenchymal crosstalk. Development. 2020 Apr 30;147(21):dev187369
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7607118
Gene symbol: Cdh1
Gene name: cadherin 1
Antibody: Anti-E-Cadherin (610181; Clone 36)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 2C Wildtype: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: latero-nasal process Present Regionally restricted 2C Wildtype Expression was lost in the epithelium between the medial and lateral nasal process after fusion.
TS19: medial-nasal process Present Regionally restricted 2C Wildtype Expression was lost in the epithelium between the medial and lateral nasal process after fusion.
Specimen 2C Esrp1KO: embryonic day 11.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Structure Level Pattern Image Note
TS19: latero-nasal process Present Regionally restricted 2C Esrp1-/- Expression persisted in the epithelium between the medial and lateral nasal processes after fusion.
TS19: medial-nasal process Present Regionally restricted 2C Esrp1-/- Expression persisted in the epithelium between the medial and lateral nasal processes after fusion.
Specimen 3A Wildtype: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: palate epithelium Present Regionally restricted 3A Wildtype top Expression in the medial epithelial seam was discontinuous following fusion.
Specimen 3A Esrp1-/-: embryonic day 16.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Structure Level Pattern Image Note
TS24: palate epithelium Present Regionally restricted 3A Esrp1-/- top The mutant displayed a fusion defect and the shelves failed to elevate in the mutants.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory