Tpm1 Immunohistochemistry Gene Expression Assay - GXD

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Gene Expression Data
Assay Details

Assay

Reference:	J:306325 Wang Y, et al., Mutations in RNA Methyltransferase Gene NSUN5 Confer High Risk of Outflow Tract Malformation. Front Cell Dev Biol. 2021;9:623394
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7580413
Gene symbol:	Tpm1
Gene name:	tropomyosin 1, alpha

Antibody:

Anti-Tropomyosin 1 (alpha) ab55915

Results

4G Nsun5+/+ top ©

Specimen 4G top Nsun5+/+: embryonic day 14.5 (more

)
Note: Double labeled: green - Tpm1; red - Tnnt2 (assay MGI:7580410).

Structure	Level	Pattern	Image	Note
TS22: outflow tract	Present		4G Nsun5+/+ top

4G Nsun5+/- top ©

Specimen 4G top Nsun5+/-: embryonic day 14.5; Nsun5^em1Lgch/Nsun5⁺ (more

)
Note: Double labeled: green - Tpm1; red - Tnnt2 (assay MGI:7580410).

Structure	Level	Pattern	Image	Note
TS22: outflow tract	Weak		4G Nsun5+/- top	Reduced expression level was observed.

4G Nsun5-/- top ©

Specimen 4G top Nsun5-/-: embryonic day 14.5; Nsun5^em1Lgch/Nsun5^em1Lgch (more

)
Note: Double labeled: green - Tpm1; red - Tnnt2 (assay MGI:7580410).

Structure	Level	Pattern	Image	Note
TS22: outflow tract	Weak		4G Nsun5-/- top	Reduced expression level was observed.

4G Nsun5+/+ bottom ©

Specimen 4G bottom Nsun5+/+: embryonic day 14.5 (more

)
Note: Double labeled: green - Tpm1; red - Tnnt2 (assay MGI:7580410).

Structure	Level	Pattern	Image	Note
TS22: interventricular septum	Present		4G Nsun5+/+ bottom

4G Nsun5+/- bottom ©

Specimen 4G bottom Nsun5+/-: embryonic day 14.5; Nsun5^em1Lgch/Nsun5⁺ (more

)
Note: Double labeled: green - Tpm1; red - Tnnt2 (assay MGI:7580410).

Structure	Level	Pattern	Image	Note
TS22: interventricular septum	Weak		4G Nsun5+/- bottom	Reduced expression level was observed.

4G Nsun5-/- bottom ©

Specimen 4G bottom Nsun5-/-: embryonic day 14.5; Nsun5^em1Lgch/Nsun5^em1Lgch (more

)
Note: Double labeled: green - Tpm1; red - Tnnt2 (assay MGI:7580410).

Structure	Level	Pattern	Image	Note
TS22: interventricular septum	Weak		4G Nsun5-/- bottom	Reduced expression level was observed.

S6C Nsun5+/+ ©

Specimen S6c Nsun5+/+: embryonic day 14.5 (more

)
Note: Double labeled: green - Tpm1; red - Tnnt2 (assay MGI:7580410).

Structure	Level	Pattern	Image	Note
TS22: compact myocardium	Present	Regionally restricted	S6C Nsun5+/+	Expression was detected in proliferating cells in the myocardial wall.

S6C Nsun5+/- ©

Specimen S6c Nsun5+/-: embryonic day 14.5; Nsun5^em1Lgch/Nsun5⁺ (more

)
Note: Double labeled: green - Tpm1; red - Tnnt2 (assay MGI:7580410).

Structure	Level	Pattern	Image	Note
TS22: compact myocardium	Weak	Regionally restricted	S6C Nsun5+/-	Reduced numbers of immunopositive cells were observed in the myocardial wall of E14.5 Nsun5+/- hearts.

S6C Nsun5-/- ©

Specimen S6c Nsun5-/-: embryonic day 14.5; Nsun5^em1Lgch/Nsun5^em1Lgch (more

)
Note: Double labeled: green - Tpm1; red - Tnnt2 (assay MGI:7580410).

Structure	Level	Pattern	Image	Note
TS22: compact myocardium	Weak	Regionally restricted	S6C Nsun5-/-	Reduced numbers of immunopositive cells were observed in the myocardial wall of E14.5 Nsun5-/- hearts.

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