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Gene Expression Data
Assay Details
Assay
Reference: J:119488 Hossain Z, et al., Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1631-6
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7574303
Gene symbol: Wwtr1
Gene name: WW domain containing transcription regulator 1
Antibody: anti-Wwtr1
Results
Specimen 3A: postnatal day 9 (more )
Note: Double labeled: red - Wwtr1; blue - DAPI.
Structure Level Pattern Image Note
TS28: metanephros Weak Non-Uniform 3A Weak non-uniform expression in glomeruli and tubules.
Specimen 3B: postnatal adult (more )
Note: Double labeled: red - Wwtr1; blue - nuclear yellow (NY).
Structure Level Pattern Image Note
TS28: glomerular tuft Weak Non-Uniform 3B Weak non-uniform expression in glomeruli and tubules.
TS28: renal tubule Weak Non-Uniform 3B Weak non-uniform expression in glomeruli and tubules.
Specimen 3C: postnatal adult; Wwtr1tm1Whun/Wwtr1tm1Whun (more )
Note: Double labeled: red - Wwtr1; blue - nuclear yellow (NY).
Structure Level Pattern Image Note
TS28: glomerular tuft Absent 3C Loss of expression in cystic glomerulus.
Specimen S6A,B,C: postnatal day 9 (more )
Note: Double labeled: red - Wwtr1; green - dolichos biflorus agglutinin (DBA).
Structure Level Pattern Image Note
TS28: collecting duct Present Non-Uniform S6C , S6A , S6B Non-uniform expression in glomeruli and collecting ducts.
TS28: glomerular tuft Present Non-Uniform S6C , S6A , S6B Non-uniform expression in glomeruli and collecting ducts.
Specimen S6D,E,F: postnatal day 9; Wwtr1tm1Whun/Wwtr1tm1Whun (more )
Note: Double labeled: red - Wwtr1; green - dolichos biflorus agglutinin (DBA).
Structure Level Pattern Image Note
TS28: metanephros Weak Regionally restricted S6D , S6E , S6F Decreased expression in kidney and collecting duct derived cysts.
Specimen S7A,B,C: postnatal day 9 (more )
Note: Double labeled: red - Wwtr1; green - lotus tetragonolobus agglutinin (LTA).
Structure Level Pattern Image Note
TS28: glomerular tuft Present Non-Uniform S7C , S7B , S7A Non-uniform expression in glomeruli and proximal tubules.
TS28: renal proximal tubule Present Non-Uniform S7C , S7B , S7A Non-uniform expression in glomeruli and proximal tubules.
Specimen S7D,E,F: postnatal day 9; Wwtr1tm1Whun/Wwtr1tm1Whun (more )
Note: Double labeled: red - Wwtr1; green - lotus tetragonolobus agglutinin (LTA).
Structure Level Pattern Image Note
TS28: metanephros Weak Regionally restricted S7F , S7E , S7D Decreased expression in kidney and proximal tubule derived dilated tubules and cysts.
Specimen S8A,B,C: postnatal day 9 (more )
Note: Double labeled: red - Wwtr1; green - Umod (assay MGI:7574304).
Structure Level Pattern Image Note
TS28: glomerular tuft Present Non-Uniform S8B , S8A , S8C Non-uniform expression in glomeruli and distal tubules.
TS28: renal distal tubule Present Non-Uniform S8B , S8A , S8C Non-uniform expression in glomeruli and distal tubules.
Specimen S8D,E,F: postnatal day 9; Wwtr1tm1Whun/Wwtr1tm1Whun (more )
Note: Double labeled: red - Wwtr1; green - Umod (assay MGI:7574304).
Structure Level Pattern Image Note
TS28: metanephros Weak S8E , S8F , S8D Authors report decreased expression in kidney.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/06/2026
MGI 6.24 		The Jackson Laboratory