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Gene Expression Data
Assay Details
Assay
Reference: J:249803 Guerrero-Flores G, et al., Functional determination of the differentiation potential of ventral mesencephalic neural precursor cells during dopaminergic neurogenesis. Dev Biol. 2017 Sep 1;429(1):56-70
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7538886
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: anti-Sox2
Results
Specimen E9.5: embryonic day 9.5 (more )
Note: Data not shown. Cell counts were graphed in Figure 1A.
Structure Cell Type Level Pattern Image Note
TS15: future midbrain neural progenitor cell Present Regionally restricted Expression was detected in the dividing midbrain dopaminergic neural progenitor cells.
Specimen E10.5: embryonic day 10.5 (more )
Note: Data not shown. Cell counts were graphed in Figure 1A.
Structure Cell Type Level Pattern Image Note
TS17: midbrain neural progenitor cell Present Regionally restricted Expression was detected in the dividing midbrain dopaminergic neural progenitor cells.
Specimen E11.5: embryonic day 11.5 (more )
Note: Data not shown. Cell counts were graphed in Figure 1A.
Structure Cell Type Level Pattern Image Note
TS19: midbrain neural progenitor cell Present Regionally restricted Expression was detected in the dividing midbrain dopaminergic neural progenitor cells.
Specimen E12.0: embryonic day 12.0 (more )
Note: Data not shown. Cell counts were graphed in Figure 1A.
Structure Cell Type Level Pattern Image Note
TS20: midbrain neural progenitor cell Present Regionally restricted Expression was detected in the dividing midbrain dopaminergic neural progenitor cells.
Specimen E12.5: embryonic day 12.5 (more )
Note: Data not shown. Cell counts were graphed in Figure 1A.
Structure Cell Type Level Pattern Image Note
TS20: midbrain neural progenitor cell Present Regionally restricted Expression was detected in the dividing midbrain dopaminergic neural progenitor cells. The number of Sox2+ cells increased linearly through E9.5 to E12.5.
Specimen 1D: embryonic day 11.5 (more )
Note: Double labeled: red - Sox2; green - BrdU.
Structure Level Pattern Image Note
TS20: brain subventricular zone Present 1D BrdU/Sox2 All of the BrdU+ cells were also Sox2+.
TS20: brain ventricular layer Present 1D BrdU/Sox2 All of the BrdU+ cells were also Sox2+.
Specimen S1B: embryonic day 12.5 (more )
Note: BrdU at E10.5. Triple labeled: red - Sox2; blue - Lmx1a (assay MGI:7538898); green - BrdU.
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted S1B Sox2 , S1B Merge top Most BrdU+ cells co-expressed Sox2, some of which displayed a weak signal.
Specimen S2A left: embryonic day 10.5 (more )
Note: Double labeled: green - Sox2; red - Lmx1a (assay MGI:7538898).
Structure Level Pattern Image Note
TS17: midbrain Present Regionally restricted S2A left Most cells in the Lmx1a+ domain were Sox2+.
Specimen S3A left: embryonic day 11.5 (more )
Note: Double labeled: green - Sox2; red - Lmx1a (assay MGI:7538898).
Structure Level Pattern Image Note
TS19: midbrain Present Regionally restricted S3A left Several Sox2+ cells were noted in the Lmx1a+ domain, and some Sox2-negative cells were detected in the most pial region.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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