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Gene Expression Data
Assay Details
Assay
Reference: J:84372 Previtali SC, et al., Expression of laminin receptors in schwann cell differentiation: evidence for distinct roles. J Neurosci. 2003 Jul 2;23(13):5520-30
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7524127
Gene symbol: Itgb4
Gene name: integrin beta 4
Antibody: anti-integrin beta4 (6945)
Assay notes: Multiple Itgb4 antibodies were described, but the one used in this assay was not detailed. Anti-integrin beta4 (beta4-cyto) MGI:7523081 or anti-integrin beta4 (346-11A) MGI:3694679 may have been used in this assay.
Results
Specimen 2F: embryonic day 18.5 (more )
Note: Double labeled: red - Itgb4; green - neurofilament.
Structure Level Pattern Image Note
TS26: spinal nerve ventral root Absent 2F No expression in motor roots.
Specimen 2G: embryonic day 18.5 (more )
Note: Double labeled: red - Itgb4; green - neurofilament.
Structure Level Pattern Image Note
TS26: peripheral nerve Absent 2G
Specimen 6A/C: postnatal day 1 (more )
Note: Double labeled: green - Itgb4; red - Mbp (assay MGI:7524128).
Structure Cell Type Level Pattern Image Note
TS27: spinal nerve ventral root Schwann cell Present Regionally restricted 6C , 6A Clearly polarized ab-axonal (ring) expression in Mbp-positive Schwann cells. Low levels of expression in Mbp-negative Schwann cells.
Specimen 6D/F: postnatal day 1 (more )
Note: Double labeled: green - Itgb4; red - Mbp (assay MGI:7524128).
Structure Cell Type Level Pattern Image Note
TS27: spinal nerve dorsal root Schwann cell Present Regionally restricted 6D , 6F Clearly polarized ab-axonal (ring) expression in Mbp-positive Schwann cells. Low levels of expression in Mbp-negative Schwann cells.
Specimen 6G/I: postnatal day 1 (more )
Note: Double labeled: green - Itgb4; red - Mbp (assay MGI:7524128).
Structure Cell Type Level Pattern Image Note
TS27: peripheral nerve Schwann cell Present Regionally restricted 6G'' , 6I' , 6I'' , 6G , 6G' , 6I Clearly polarized ab-axonal (ring) expression in Mbp-positive Schwann cells. Low levels of expression in Mbp-negative Schwann cells.
Specimen 8D: embryonic day 17.5; Itgb1tm1Lscd/Itgb1tm1Mll, Tg(Mpz-cre)26Mes/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: sciatic nerve Absent 8D Expression not prematurely induced.
Specimen 8F beta4: postnatal day 28; Itgb1tm1Lscd/Itgb1tm1Mll, Tg(Mpz-cre)26Mes/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: spinal nerve ventral root Present 8F beta4
Specimen 9K: postnatal adult; Lama2dy-2J/Lama2dy-2J (more )
Structure Level Pattern Image Note
TS28: spinal nerve root Present 9K
Specimen 9U: postnatal adult; Lama2dy-2J/Lama2dy-2J (more )
Structure Level Pattern Image Note
TS28: sciatic nerve Present 9U
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
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