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Gene Expression Data
Assay Details
Assay
Reference: J:224892 Yan Y, et al., Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2. Nat Commun. 2015;6:7006
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7520133
Gene symbol: Mki67
Gene name: antigen identified by monoclonal antibody Ki 67
Antibody: Anti-Ki67 (ab15580)
Detection system: Secondary antibody
Results
Specimen 3a +/y: embryonic day 9.5 (more )
Note: Double labeled: green - Mki67; red - BrdU.
Structure Level Pattern Image Note
TS15: future spinal cord Present 3a
Specimen 3b +/y: embryonic day 9.5 (more )
Note: Double labeled: green - Mki67; red - Foxm1 (assay MGI:7520136).
Structure Level Pattern Image Note
TS15: future spinal cord Present 3b
Specimen 3c +/y: embryonic day 9.5 (more )
Note: Double labeled: green - Mki67; red - BrdU.
Structure Level Pattern Image Note
TS15: future spinal cord Present 3c
Specimen 3e -y or -/-: embryonic day 9.5; Prdx4tm1.1Jufu/Y (more )
Note: The sex of the specimen was not specified. Double labeled: green - Mki67; red - BrdU.
Structure Level Pattern Image Note
TS15: future spinal cord Present 3e The total number of BrdU+Mki67+ cells in the mutants was reduced by 27% compared with wild-type siblings when a 16h BrdU pulse was administered. In addition, cell cycle exit indices (BrdU+Ki67-: BrdU+Ki67+) were increased by ~60% compared with wild-type littermates.
Specimen 3f -y or -/-: embryonic day 9.5; Prdx4tm1.1Jufu/? (more )
Note: The sex of the specimen was not specified. Double labeled: green - Mki67; red - Foxm1 (assay MGI:7520136).
Structure Level Pattern Image Note
TS15: future spinal cord Present 3f No change in M-phase (Mpm2/Foxm1+;Mki67+) was observed compared with the control.
Specimen 3g -y or -/-: embryonic day 9.5; Prdx4tm1.1Jufu/? (more )
Note: The sex of the specimen was not specified. Double labeled: green - Mki67; red - BrdU.
Structure Level Pattern Image Note
TS15: future spinal cord Present 3g No changes in the proportion of cells in S-phase after a 30-min BrdU pulse, compared with the control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory