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Gene Expression Data
Assay Details
Assay
Reference: J:84706 Assimacopoulos S, et al., Identification of a Pax6-dependent epidermal growth factor family signaling source at the lateral edge of the embryonic cerebral cortex. J Neurosci. 2003 Jul 23;23(16):6399-403
Assay type: RNA in situ
MGI Accession ID: MGI:7518933
Gene symbol: Nrg1
Gene name: neuregulin 1
Probe: IMAGE clone 1449986
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 2B: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: cortical antihem Present 2B Peak of expression overlapping with that of Tgfa in curving longitudinal band of cortical antihem

Specimen 3C: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: telencephalon Present Graded 3C Expression peaks in Tgfa-expressing domain but dxtends as a decreasing gradient into dorsolateral cortical neuroepithelium, with an additional zone of expression in medial cortical primodrium.

Specimen 3H: embryonic day 12.5 (more )
Note: Double labeled: blue - Nrg1; red - Sfrp2 (assay MGI:7518929).
Structure Level Pattern Image Note
TS20: cerebral cortex Present 3H Expression in cortical neuroepithelium.
TS20: telencephalon ventricular layer Present Regionally restricted 3H Expression extends into ventricular zone of basal telencephalon.

Specimen 4G: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cortical antihem Present 4G Dense expression at antihem region at E14.5

Specimen 4H: embryonic day 14.5; Pax6Sey/Pax6Sey (more )
Structure Level Pattern Image Note
TS22: telencephalon Present Regionally restricted 4H Expression missing from antihem region.
TS22: cerebral cortex ventricular layer Trace Regionally restricted 4H Expression in lateral cortical ventricular zone almost undetectable.
TS22: hippocampus Present 4H Expression remains in hippocampal primordium.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory