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Gene Expression Data
Assay Details
Assay
Reference: J:191149 Alves CH, et al., Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet. 2013 Jan 1;22(1):35-50
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7507167
Gene symbol: Sox9
Gene name: SRY (sex determining region Y)-box 9
Antibody: Anti-SOX9
Detection system: Secondary antibody coupled to Cy3
Results
Specimen 10G: postnatal month 3; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-. Double labeled: red - Sox9; green - Glul (assay MGI:7511531).
Structure Cell Type Level Pattern Image Note
TS28: retina Mueller cell Present 10G
Specimen 10H: postnatal month 3; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant. Double labeled: red - Sox9; green - Glul (assay MGI:7511531).
Structure Cell Type Level Pattern Image Note
TS28: retina outer nuclear layer Mueller cell Present 10H Ectopic Muller glia cells were detected in the mutant outer nuclear layer.
TS28: retina Present 10H An increase of 12% total immunopositive Sox9 cells was seen compared with controls.
Specimen S6A: postnatal day 10; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-.
Structure Cell Type Level Pattern Image Note
TS28: retina Mueller cell Present S6A
Specimen S6B: postnatal day 10; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: retina Mueller cell Present S6B At P10, the Muller glia were not affected in the cKO.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory