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Gene Expression Data
Assay Details
Assay
Reference: J:184591 Aoyama M, et al., Spatial Restriction of Bone Morphogenetic Protein Signaling in Mouse Gastrula through the mVam2-Dependent Endocytic Pathway. Dev Cell. 2012 Jun 12;22(6):1163-75
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7464760
Gene symbol: Bmpr1a
Gene name: bone morphogenetic protein receptor, type 1A
Antibody: anti-Bmpr1a
Detection system: Secondary antibody
Results
Specimen 6A Bmpr1a WT: embryonic day 6.2 (more )
Note: Triple labeled: red - Bmpr1a; green - Rab7 (assay MGI:7464737); blue - Lamp2 (assay MGI:7464741).
Structure Level Pattern Image Note
TS8: primitive endoderm Present Regionally restricted 6A WT , 6A WT inset Expression highly accumulated on apical surface, with lesser amount on basolateral plasma membrane.
Specimen 6A Bmpr1a mVam2-/-: embryonic day 6.2; Vps41tm1.1Ywd/Vps41tm1.1Ywd (more )
Note: Triple labeled: red - Bmpr1a; green - Rab7 (assay MGI:7464737); blue - Lamp2 (assay MGI:7464741).
Structure Level Pattern Image Note
TS8: primitive endoderm Present Regionally restricted 6A mVam2-/- inset , 6A mVam2-/- Decreased surface expression.
Specimen S5A Bmpr1a wild-type (left): embryonic day 6.0 (more )
Note: Triple labeled: red - Bmpr1a; green - Rab7 (assay MGI:7464737); blue - Lamp2 (assay MGI:7464741).
Structure Level Pattern Image Note
TS8: primitive endoderm Present Regionally restricted S5A wild-type Bmpr1a inset , S5A wild-type Bmpr1a (upper) Expression highly accumulated on apical surface, with lesser amount on basolateral plasma membrane.
Specimen S5A Bmpr1a wild-type (right): embryonic day 6.0 (more )
Note: Triple labeled: red - Bmpr1a; green - Rab7 (assay MGI:7464737); blue - Lamp2 (assay MGI:7464741).
Structure Level Pattern Image Note
TS8: primitive endoderm Present Regionally restricted S5A Bmpr1a/lamp2/rab7 wild-type Expression highly accumulated on apical surface, with lesser amount on basolateral plasma membrane.
Specimen S5A Bmpr1a mVam2-/-: embryonic day 6.0; Vps41tm1.1Ywd/Vps41tm1.1Ywd (more )
Note: Triple labeled: red - Bmpr1a; green - Rab7 (assay MGI:7464737); blue - Lamp2 (assay MGI:7464741).
Structure Level Pattern Image Note
TS8: primitive endoderm Present Regionally restricted S5A Bmpr1a/lamp2/rab7 mVam2-/- Decreased surface expression.
Specimen S5C wild-type: embryonic day 6.0 (more )
Note: Double labeled: red - Bmpr1a; green - Rab7 (assay MGI:7464737).
Structure Level Pattern Image Note
TS8: primitive endoderm Present Regionally restricted S5C wild-type (upper) , S5C wild-type (lower) Expression in lumen and membranes of apical vacuoles.
Specimen S5C mVam2-/-: embryonic day 6.0; Vps41tm1.1Ywd/Vps41tm1.1Ywd (more )
Note: Double labeled: red - Bmpr1a; green - Rab7 (assay MGI:7464737).
Structure Level Pattern Image Note
TS8: primitive endoderm Present Regionally restricted S5C mVam2-//- (upper) , S5C mVam2-/- (lower) Expression mostly in periphery, but some in lumen.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory