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Gene Expression Data
Assay Details
Assay
Reference: J:314694 Douchi D, et al., Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus. Gastroenterology. 2021 Dec;161(6):1907-1923.e26
Assay type: RNA in situ
MGI Accession ID: MGI:7463961
Gene symbol: Lgr5
Gene name: leucine rich repeat containing G protein coupled receptor 5
Probe: Mm-Lgr5 (312171)
Probe preparation: Antisense
Visualized with: Chromogenic
Assay notes: RNAscope assay.
Results
Specimen S3A - Lgr5: postnatal adult (more )
Note: Double labeled: blue - Lgr5; red - Mki67 (assay MGI:7463941).
Structure Cell Type Level Pattern Image Note
TS28: stomach glandular region gastric gland Present Regionally restricted S3A Lgr5 , S3A Lgr5 Isthmus Expression is mainly detected in the gland base, although rare expression can also be observed in the isthmus.
TS28: stomach glandular region epithelium peptic cell Present S3A Lgr5 Expression is seen in chief cells.
Specimen S3B - Lgr5: postnatal adult; Pgctm1.1(cre/ERT2)Itoy/Pgc+ (more )
Note: Double labeled: blue - Lgr5; red - Pgc (assay MGI:7461896).
Structure Cell Type Level Pattern Image Note
TS28: stomach glandular region gastric gland Present Regionally restricted S3B Lgr5 Base , S3B Lgr5 Isthmus , S3B Lgr5 Expression is mainly detected in the gland base, although rare expression can also be observed in the isthmus.
TS28: stomach glandular region epithelium peptic cell Present S3B Lgr5 Base , S3B Lgr5 Expression is seen in chief cells.
Specimen S4E: postnatal adult (more )
Note: Double labeled: blue - Lgr5; red - Mki67 (assay MGI:7463941).
Structure Cell Type Level Pattern Image Note
TS28: stomach glandular region gastric gland Present Regionally restricted S4E Base , S4E , S4E Isthmus Expression is mainly detected in the gland base, although rare expression can also be observed in the isthmus.
TS28: stomach glandular region epithelium peptic cell Present S4E , S4E Base Expression is seen in chief cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
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