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Gene Expression Data
Assay Details
Assay
Reference: J:268713 Schweiger PJ, et al., Lrig1 marks a population of gastric epithelial cells capable of long-term tissue maintenance and growth in vitro. Sci Rep. 2018 Oct 15;8(1):15255
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7443063
Gene symbol: Lrig1
Gene name: leucine-rich repeats and immunoglobulin-like domains 1
Antibody: anti-Lrig1 (AF3688)
Detection system: Secondary antibody coupled to Alexa Fluor 555
Results
Specimen 1B - small intestine: postnatal (more )
Structure Level Pattern Image Note
TS28: small intestine crypt of lieberkuhn Present Regionally restricted 1B Small intestine - lower Expression is seen in cells at the bottom of the crypt.
Specimen 1B - skin: postnatal (more )
Structure Level Pattern Image Note
TS28: epidermis Present Regionally restricted 1B Skin - lower Expression is seen within the junctional zone of the pilosebaceous unit in the epidermis.
Specimen 1C - stomach: postnatal (more )
Structure Level Pattern Image Note
TS28: body of stomach Present 1C Mouse stomach
TS28: stomach proventricular region Present 1C Mouse stomach
TS28: stomach pyloric region Present 1C Mouse stomach
Specimen 1C - corpus: postnatal (more )
Structure Level Pattern Image Note
TS28: body of stomach Present Regionally restricted 1C Corpus Expression is seen in a discrete subset of cells located at the bottom of the glands.
TS28: stomach glandular epithelium Present Regionally restricted 1C Corpus Expression is seen in a discrete subset of cells located at the bottom of the glands.
Specimen 1C - pylorus: postnatal (more )
Structure Level Pattern Image Note
TS28: stomach glandular epithelium Present Regionally restricted 1C Pylorus Expression is seen in a discrete subset of cells located at the bottom of the glands.
TS28: stomach pyloric region Present Regionally restricted 1C Pylorus Expression is seen in a discrete subset of cells located at the bottom of the glands.
Specimen 1F - corpus: postnatal; Lrig1tm1(cre/ERT2)Kjen/Lrig1+ (more )
Note: Double labeled: red - Lrig1 protein; green - Lrig1 reporter (assay MGI:7442842).
Structure Level Pattern Image Note
TS28: body of stomach Present Regionally restricted 1F Corpus Expression is seen in a discrete subset of cells located at the bottom of the glands.
TS28: stomach glandular region Present Regionally restricted 1F Corpus Expression is seen in a discrete subset of cells located at the bottom of the glands.
Specimen 1F - pylorus: postnatal; Lrig1tm1(cre/ERT2)Kjen/Lrig1+ (more )
Note: Double labeled: red - Lrig1 protein; green - Lrig1 reporter (assay MGI:7442842).
Structure Level Pattern Image Note
TS28: stomach glandular epithelium Present Regionally restricted 1F Pylorus Expression is seen in a discrete subset of cells located at the bottom of the glands.
TS28: stomach pyloric region Present Regionally restricted 1F Pylorus Expression is seen in a discrete subset of cells located at the bottom of the glands.
Specimen 1F - forestomach: postnatal; Lrig1tm1(cre/ERT2)Kjen/Lrig1+ (more )
Note: Double labeled: red - Lrig1 protein; green - Lrig1 reporter (assay MGI:7442842).
Structure Level Pattern Image Note
TS28: stomach proventricular region epithelium Present Widespread 1F Forestomach Ubiquitous expression is seen in the basal layer.
Specimen 2E - K10: postnatal (more )
Note: Double labeled: red - Lrig1; green - Krt10 (assay MGI:7443070).
Structure Level Pattern Image Note
TS28: stomach proventricular region epithelium Present Regionally restricted 2E K10 No overlap in expression with keratin 10.
Specimen 2E - K14: postnatal (more )
Note: Double labeled: red - Lrig1; green - Krt14 (assay MGI:7443071).
Structure Level Pattern Image Note
TS28: stomach proventricular region epithelium Present Regionally restricted 2E K14 There is overlap in expression with keratin 14 expression in the basal layer.
Specimen 2E - EdU: postnatal (more )
Note: Also labeled for EdU (green).
Structure Level Pattern Image Note
TS28: stomach proventricular region epithelium Present Regionally restricted 2E EdU Expression is seen in the basal layer; some of these cells are dividing.
Specimen 2F: postnatal; Lgr5tm1(cre/ERT2)Cle/Lgr5+ (more )
Note: Double labeled: red - Lrig1; green - Lrg5 reporter (assay MGI:7443069).
Structure Level Pattern Image Note
TS28: stomach glandular epithelium Present Regionally restricted 2F Expression overlaps with, but is not limited to Lgr5 expressing cells.
TS28: stomach pyloric region Present Regionally restricted 2F Expression overlaps with, but is not limited to Lgr5 expressing cells.
Specimen 2G - left: postnatal (more )
Note: Double labeled: red - Lrig1; green - Atp4a (assay MGI:7443068).
Structure Level Pattern Image Note
TS28: body of stomach Present Regionally restricted 2G left Many cells also express Atp4a.
Specimen 2H - corpus: postnatal (more )
Note: Also labeled for EdU (green).
Structure Level Pattern Image Note
TS28: body of stomach Present 2H Corpus Few of the expressing cells are also dividing.
Specimen 2H - pylorus: postnatal (more )
Note: Also labeled for EdU (green).
Structure Level Pattern Image Note
TS28: stomach pyloric region Present 2H Pylorus Few of the expressing cells are also dividing.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/28/2024
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