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Gene Expression Data
Assay Details
Assay
Reference: J:311142 Sun H, et al., Gpr125 Marks Distinct Cochlear Cell Types and Is Dispensable for Cochlear Development and Hearing. Front Cell Dev Biol. 2021;9:690955
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7384738
Gene symbol: Cd44
Gene name: CD44 antigen
Antibody: anti-CD44 (IM7)
Detection system: Secondary antibody coupled to Alexa Fluor 647
Results
Specimen 1A: embryonic day 15.5; Adgra3tm1Dgen/Adgra3+ (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Level Pattern Image Note
TS23: lesser epithelial ridge Present Regionally restricted 1A Only in the basal turn.
TS23: cochlear duct mesenchyme Present Regionally restricted 1A Occasionally expressed in the periotic mesenchyme surrounding the cochlear duct.
Specimen 1B/B' Apex: embryonic day 15.5 (more )
Note: Double labeled: red - Cd44; blue - Myo7a (assay MGI:7384739).
Structure Level Pattern Image Note
TS23: cochlear duct mesenchyme Present Regionally restricted 1B' , 1B Expressed in the periotic mesenchyme surrounding the cochlear duct.
Specimen 1C/C' Middle: embryonic day 15.5 (more )
Note: Double labeled: red - Cd44; blue - Myo7a (assay MGI:7384739).
Structure Level Pattern Image Note
TS23: cochlear duct mesenchyme Present Regionally restricted 1C , 1C' Expressed in the periotic mesenchyme surrounding the cochlear duct.
Specimen 1D/D' Base: embryonic day 15.5 (more )
Note: Double labeled: red - Cd44; blue - Myo7a (assay MGI:7384739).
Structure Level Pattern Image Note
TS23: lesser epithelial ridge Present 1D , 1D'
TS23: cochlear duct mesenchyme Present Regionally restricted 1D' , 1D Expressed in the periotic mesenchyme surrounding the cochlear duct.
Specimen 1E/E' Apex: embryonic day 15.5; Adgra3tm1Dgen/Adgra3+ (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Level Pattern Image Note
TS23: cochlear duct mesenchyme Present Regionally restricted 1E , 1E' Expressed in the periotic mesenchyme surrounding the cochlear duct.
Specimen 1F/F' Middle: embryonic day 15.5; Adgra3tm1Dgen/Adgra3+ (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Level Pattern Image Note
TS23: cochlear duct mesenchyme Present Regionally restricted 1F' , 1F Expressed in the periotic mesenchyme surrounding the cochlear duct.
Specimen 1G/G' Base: embryonic day 15.5; Adgra3tm1Dgen/Adgra3+ (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Level Pattern Image Note
TS23: lesser epithelial ridge Present 1G , 1G' Expression overlapped with beta-Gal expression.
TS23: cochlear duct mesenchyme Present Regionally restricted 1G' , 1G Expressed in the periotic mesenchyme surrounding the cochlear duct.
Specimen 2A: embryonic day 18.5; Adgra3tm1Dgen/Adgra3+ (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Cell Type Level Pattern Image Note
TS26: lesser epithelial ridge Present 2A Coexpressed with Adgra3.
TS26: cochlear duct inner phalangeal cell Present 2A
TS26: cochlear duct mesenchyme Present Regionally restricted 2A Expressed in the mesenchymal cells outside the roof.
Specimen 2B: embryonic day 18.5 (more )
Note: Double labeled: red - Cd44; blue - Myo7a (assay MGI:7384739).
Structure Cell Type Level Pattern Image Note
TS26: lesser epithelial ridge Present 2B
TS26: cochlear duct inner phalangeal cell Present 2B
TS26: cochlear duct mesenchyme Present Regionally restricted 2B Expressed in the mesenchymal cells outside the roof.
Specimen 2C: embryonic day 18.5 (more )
Note: Double labeled: red - Cd44; blue - Myo7a (assay MGI:7384739).
Structure Cell Type Level Pattern Image Note
TS26: lesser epithelial ridge Present 2C
TS26: cochlear duct inner phalangeal cell Present 2C
Specimen 2D: embryonic day 18.5; Adgra3tm1Dgen/Adgra3+ (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Cell Type Level Pattern Image Note
TS26: lesser epithelial ridge Present Regionally restricted 2D Coexpressed with Adgra3. Not expressed in medial lesser epithelial ridge cells.
TS26: cochlear duct inner phalangeal cell Present 2D
TS26: cochlear duct mesenchyme Present Regionally restricted 2D Expressed in the mesenchymal cells outside the roof.
Specimen 2E: embryonic day 18.5; Adgra3tm1Dgen/Adgra3+ (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Cell Type Level Pattern Image Note
TS26: lesser epithelial ridge Present 2E Coexpressed with Adgra3.
TS26: cochlear duct inner phalangeal cell Present 2E
Specimen 2F: embryonic day 18.5 (more )
Note: Double labeled: red - Cd44; blue - Myo7a (assay MGI:7384739).
Structure Cell Type Level Pattern Image Note
TS26: lesser epithelial ridge Present 2F
TS26: cochlear duct inner phalangeal cell Present 2F
TS26: cochlear duct mesenchyme Present 2F Expressed in the mesenchymal cells outside the roof.
Specimen 2G: embryonic day 18.5 (more )
Note: Double labeled: red - Cd44; blue - Myo7a (assay MGI:7384739).
Structure Cell Type Level Pattern Image Note
TS26: lesser epithelial ridge Present 2G
TS26: cochlear duct inner phalangeal cell Present 2G
Specimen 2H: embryonic day 18.5; Adgra3tm1Dgen/Adgra3+ (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Level Pattern Image Note
TS26: lesser epithelial ridge Present 2H Coexpressed with Adgra3. Not expressed in medial lesser epithelial ridge cells.
Specimen 2I: embryonic day 18.5; Adgra3tm1Dgen/Adgra3+ (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Level Pattern Image Note
TS26: lesser epithelial ridge Present 2I Coexpressed with Adgra3.
Specimen 2J: embryonic day 18.5 (more )
Note: Double labeled: red - Cd44; blue - Myo7a (assay MGI:7384739).
Structure Cell Type Level Pattern Image Note
TS26: lesser epithelial ridge Present 2J
TS26: cochlear duct inner phalangeal cell Present 2J
TS26: cochlear duct mesenchyme Present Regionally restricted 2J Expressed in the mesenchymal cells outside the roof.
Specimen 2K: embryonic day 18.5 (more )
Note: Double labeled: red - Cd44; blue - Myo7a (assay MGI:7384739).
Structure Level Pattern Image Note
TS26: lesser epithelial ridge Present 2K Coexpressed with Adgra3.
Specimen 2L: embryonic day 18.5; Adgra3tm1Dgen/Adgra3+ (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Level Pattern Image Note
TS26: lesser epithelial ridge Present 2L Coexpressed with Adgra3. Not expressed in medial lesser epithelial ridge cells.
Specimen 2M: embryonic day 18.5; Adgra3tm1Dgen/Adgra3+ (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Level Pattern Image Note
TS26: lesser epithelial ridge Present 2M Coexpressed with Adgra3.
Specimen 3A/A': postnatal day 0; Adgra3tm1Dgen/Adgra3+ (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Cell Type Level Pattern Image Note
TS27: cochlea epithelium Claudius cell Present 3A , 3A'
Specimen 3B/B'/B": postnatal day 4; Adgra3tm1Dgen/Adgra3+ (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Cell Type Level Pattern Image Note
TS28: cochlea epithelium Claudius cell Present 3B' , 3B , 3B"
Specimen 3C/C': postnatal day 0; Adgra3tm1Dgen/Adgra3+ (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Cell Type Level Pattern Image Note
TS27: cochlea epithelium Claudius cell Present 3C , 3C'
Specimen 3D/D': postnatal day 4; Adgra3tm1Dgen/Adgra3+ (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Cell Type Level Pattern Image Note
TS28: cochlea epithelium Claudius cell Present 3D' , 3D
Specimen 3E/E': postnatal day 30; Adgra3tm1Dgen/Adgra3+ (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Cell Type Level Pattern Image Note
TS28: cochlea epithelium Claudius cell Present 3E , 3E'
Specimen 3F/F': postnatal day 30; Adgra3tm1Dgen/Adgra3+ (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Cell Type Level Pattern Image Note
TS28: cochlea epithelium Claudius cell Present 3F' , 3F
Specimen 6Q: embryonic day 15.5 (more )
Note: Double labeled: red - Cd44; blue - Myo7a (assay MGI:7384739).
Structure Level Pattern Image Note
TS23: cochlear duct mesenchyme Present Regionally restricted 6Q Expressed in the periotic mesenchyme surrounding the cochlear duct.
Specimen 6R: embryonic day 15.5; Adgra3tm1Dgen/Adgra3tm1Dgen (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Level Pattern Image Note
TS23: cochlear duct mesenchyme Present Regionally restricted 6R Expressed in the periotic mesenchyme surrounding the cochlear duct, similar as in the wild-type.
Specimen 6S: embryonic day 18.5 (more )
Note: Double labeled: red - Cd44; blue - Myo7a (assay MGI:7384739).
Structure Level Pattern Image Note
TS26: lesser epithelial ridge Present 6S
TS26: cochlear duct mesenchyme Present Regionally restricted 6S Expressed in the periotic mesenchyme surrounding the cochlear duct.
Specimen 6T: embryonic day 18.5; Adgra3tm1Dgen/Adgra3tm1Dgen (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Level Pattern Image Note
TS26: lesser epithelial ridge Present 6T Similar as in the wild-type.
TS26: cochlear duct mesenchyme Present Regionally restricted 6T Expressed in the periotic mesenchyme surrounding the cochlear duct, similar as in the wild-type.
Specimen 6U: postnatal day 0 (more )
Note: Double labeled: red - Cd44; blue - Myo7a (assay MGI:7384739).
Structure Cell Type Level Pattern Image Note
TS27: cochlea epithelium Claudius cell Present 6U
Specimen 6V: postnatal day 0; Adgra3tm1Dgen/Adgra3tm1Dgen (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Cell Type Level Pattern Image Note
TS27: cochlea epithelium Claudius cell Present 6V Similar as in the wild-type.
Specimen 6W: postnatal day 4 (more )
Note: Double labeled: red - Cd44; blue - Myo7a (assay MGI:7384739).
Structure Cell Type Level Pattern Image Note
TS28: cochlea epithelium Claudius cell Present 6W
Specimen 6X: postnatal day 4; Adgra3tm1Dgen/Adgra3tm1Dgen (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Cell Type Level Pattern Image Note
TS28: cochlea epithelium Claudius cell Present 6X Similar as in the wild-type.
Specimen 6Y: postnatal day 30 (more )
Note: Double labeled: red - Cd44; blue - Myo7a (assay MGI:7384739).
Structure Cell Type Level Pattern Image Note
TS28: cochlea epithelium Claudius cell Present 6Y
Specimen 6Z: postnatal day 30; Adgra3tm1Dgen/Adgra3tm1Dgen (more )
Note: Triple labeled: red - Cd44; blue - Myo7a (assay MGI:7384739); green - Adgra3 (assay MGI:7384688).
Structure Cell Type Level Pattern Image Note
TS28: cochlea epithelium Claudius cell Present 6Z Similar as in the wild-type.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
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