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Gene Expression Data
Assay Details
Assay
Reference: J:329314 Wang Y, et al., Notch1 down-regulation in lineage-restricted niches is involved in the development of mouse eccrine sweat glands. J Mol Histol. 2022 Oct;53(5):857-867
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7346145
Gene symbol: Notch1
Gene name: notch 1
Antibody: anti-Notch1 (D1E11) (3608)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 4a2,a4: embryonic day 12.5 (more )
Note: Double labeled: green - Notch1; red - Krt14 (assay MGI:7346147).
Structure Level Pattern Image Note
TS20: foot Strong Widespread 4a4 , 4a2 Highly and widely expressed in skin basal layers, dermis and blood vessels.
Specimen 4b2,b4: embryonic day 17.5 (more )
Note: Double labeled: green - Notch1; red - Krt14 (assay MGI:7346147).
Structure Level Pattern Image Note
TS25: foot dermis Weak Regionally restricted 4b2 , 4b4 Expression significantly decreased all over dermis, especially in basal layers. Few expressing cells, colocalized with Drt14 expression, in basal layers.
TS25: integumental system gland Trace 4b4 , 4b2 Expressing cells almost disappeared in sweat gland buds.
Specimen 4c2,c4: postnatal day 1 (more )
Note: Double labeled: green - Notch1; red - Krt14 (assay MGI:7346147).
Structure Level Pattern Image Note
TS27: plantar pad Weak Regionally restricted 4c4 , 4c2
TS27: sweat gland Trace 4c4 , 4c2 Expressing cells almost disappeared in newly-formed glandular structures.
Specimen 4d2,d4: postnatal day 5 (more )
Note: Double labeled: green - Notch1; red - Krt14 (assay MGI:7346147).
Structure Level Pattern Image Note
TS28: plantar pad Trace Regionally restricted 4d4 , 4d2 Overall distribution of expression continuously decreased at P5. Few expressing cells, colocalized with Drt14 expression, in deeper dermis.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory