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Gene Expression Data
Assay Details
Assay
Reference: J:326355 Bademci G, et al., Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2204084119
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7329777
Gene symbol: Nefm
Gene name: neurofilament, medium polypeptide
Antibody: anti-neurofilament clone 2H3
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen S7 +/+: postnatal day 1 (more )
Note: Double labeled: green - Nefm; magenta - Myo7a (assay MGI:7329775).
Structure Level Pattern Image Note
TS27: organ of Corti Present S7_Minar2 +/+
Specimen S7 tm1b/tm1b: postnatal day 1; Minar2tm1b(KOMP)Wtsi/Minar2tm1b(KOMP)Wtsi (more )
Note: Double labeled: green - Nefm; magenta - Myo7a (assay MGI:7329775).
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted S7_Minar2 tm1b/tm1b Reduction of nerve fibers around inner hair cells and dispersed distribution of nerve fibers toward outer hair cells.
Specimen 7A +/+ Base: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: cochlea Present 7A +/+ Base
Specimen 7A tm1b/tm1b Base: postnatal day 1; Minar2tm1b(KOMP)Wtsi/Minar2tm1b(KOMP)Wtsi (more )
Structure Level Pattern Image Note
TS27: cochlea Present 7A tm1b/tm1b Base
Specimen 7A +/+ Middle: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: cochlea Present 7A +/+ Middle
Specimen 7A tm1b/tm1b Middle: postnatal day 1; Minar2tm1b(KOMP)Wtsi/Minar2tm1b(KOMP)Wtsi (more )
Structure Level Pattern Image Note
TS27: cochlea Present 7A tm1b/tm1b Middle
Specimen 7A +/+ Apex: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: cochlea Present 7A +/+ Apex
Specimen 7A tm1b/tm1b Apex: postnatal day 1; Minar2tm1b(KOMP)Wtsi/Minar2tm1b(KOMP)Wtsi (more )
Structure Level Pattern Image Note
TS27: cochlea Present 7A tm1b/tm1b Apex
Specimen 7B +/+ Base: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: cochlea Present 7B +/+ Base
Specimen 7B tm1b/tm1b Base: postnatal day 14; Minar2tm1b(KOMP)Wtsi/Minar2tm1b(KOMP)Wtsi (more )
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted 7B tm1b/tm1b Base Reduction in number of crossings of type II nerves.
Specimen 7B +/+ Middle: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: cochlea Present 7B +/+ Middle
Specimen 7B tm1b/tm1b Middle: postnatal day 14; Minar2tm1b(KOMP)Wtsi/Minar2tm1b(KOMP)Wtsi (more )
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted 7B tm1b/tm1b Middle Reduction in number of crossings of type II nerves.
Specimen 7B +/+ Apex: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: cochlea Present 7B +/+ Apex
Specimen 7B tm1b/tm1b Apex: postnatal day 14; Minar2tm1b(KOMP)Wtsi/Minar2tm1b(KOMP)Wtsi (more )
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted 7B tm1b/tm1b Apex Reduction in number of crossings of type II nerves.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory