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Gene Expression Data
Assay Details
Assay
Reference: J:320381 Prakash R, et al., XRCC3 loss leads to midgestational embryonic lethality in mice. DNA Repair (Amst). 2021 Dec;108:103227
Assay type: RNA in situ
MGI Accession ID: MGI:7310241
Gene symbol: Fgf8
Gene name: fibroblast growth factor 8
Probe: Fgf8 probe132
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1F +/+: embryonic day 8.25 (more )
Structure Level Pattern Image Note
TS13: branchial arch Present 1F +/+
TS13: midbrain-hindbrain junction Present 1F +/+
TS13: future brain neural fold Present Regionally restricted 1F +/+ Expression is in the anterior neural ridge.
TS13: primitive streak Present Regionally restricted 1F +/+ Expression is at the posterior end.
Specimen 1F +/delta11: embryonic day 8.25; Xrcc3em4Mjn/Xrcc3+ (more )
Structure Level Pattern Image Note
TS13: branchial arch Present 1F +/delta11
TS13: midbrain-hindbrain junction Present 1F +/delta11
TS13: future brain neural fold Present Regionally restricted 1F +/delta11 Expression is in the anterior neural ridge.
TS13: primitive streak Present Regionally restricted 1F +/delta11 Expression is at the posterior end.
Specimen 1F delta11/delta11: embryonic day 8.25; Xrcc3em4Mjn/Xrcc3em4Mjn (more )
Structure Level Pattern Image Note
TS13: branchial arch Present 1F delta11/delta11 Expression in this tissue is the same as in wild-type.
TS13: primitive streak Present 1F delta11/delta11 Expression in this tissue is the same as in wild-type.
TS13: future brain neural fold Absent 1F delta11/delta11
TS13: midbrain-hindbrain junction Absent 1F delta11/delta11
Specimen 1F +/delta22: embryonic day 8.25; Xrcc3em5Mjn/Xrcc3+ (more )
Note: Also stained for Nkx2-5 (assay MGI:7310246).
Structure Level Pattern Image Note
TS13: branchial arch Present 1F Fgf8/Nkx2.5 +/delta22
TS13: midbrain-hindbrain junction Present 1F Fgf8/Nkx2.5 +/delta22
TS13: future brain neural fold Present Regionally restricted 1F Fgf8/Nkx2.5 +/delta22 Expression is in the anterior neural ridge.
TS13: primitive streak Present Regionally restricted 1F Fgf8/Nkx2.5 +/delta22 Expression is at the posterior end.
Specimen 1F delta22/delta22: embryonic day 8.25; Xrcc3em5Mjn/Xrcc3em5Mjn (more )
Note: Also stained for Nkx2-5 (assay MGI:7310246).
Structure Level Pattern Image Note
TS13: branchial arch Present 1F Fgf8/Nkx2.5 deltra22/delta22
TS13: future brain neural fold Present 1F Fgf8/Nkx2.5 deltra22/delta22
TS13: midbrain-hindbrain junction Present 1F Fgf8/Nkx2.5 deltra22/delta22
TS13: primitive streak Present 1F Fgf8/Nkx2.5 deltra22/delta22
Specimen 2K +/KA: embryonic day 8.25; Xrcc3em2Mjn/Xrcc3+ (more )
Structure Level Pattern Image Note
TS13: embryo Present 2K +/KA
Specimen 2K KA/KA 2/7: embryonic day 8.25; Xrcc3em2Mjn/Xrcc3em2Mjn (more )
Structure Level Pattern Image Note
TS13: embryo Present 2K KA/KA 2/7 Two out of seven mutant embryos were grossly normal.
Specimen 2K KA/KA 5/7: embryonic day 8.25; Xrcc3em2Mjn/Xrcc3em2Mjn (more )
Structure Level Pattern Image Note
TS13: embryo Present 2K KA/KA 5/7 Five out of seven embryos were developmentally delayed.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory