App<em3Bwef> Endonuclease-mediated Allele Detail MGI Mouse (MGI:7281307)

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App^em3Bwef
Endonuclease-mediated Allele Detail

Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Summary

Symbol:	App^em3Bwef
Name:	amyloid beta precursor protein; endonuclease-mediated mutation 3, Benedikt Wefers
MGI ID:	MGI:7281307
Gene:	App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
Alliance:	App^em3Bwef page

Mutation
origin

Strain of Origin:

C57BL/6J

Mutation
description

Allele Type:		Endonuclease-mediated (Null/knockout)
Mutation:		Intragenic deletion
		CRISPR/Cas9-mediated 123 bp deletion in exon 14 (ENSMUSE00000131686) of App. (J:360198)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any App Mutation:	120 strains or lines available

References

Original:	J:360198 Dunot J, et al., APP fragment controls both ionotropic and non-ionotropic signaling of NMDA receptors. Neuron. 2024 Jun 7;
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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