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Gene Expression Data
Assay Details
Assay
Reference: J:185870 Hazen VM, et al., BMP receptor-activated Smads confer diverse functions during the development of the dorsal spinal cord. Dev Biol. 2012 Jul 15;367(2):216-27
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6727048
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Antibody: Anti-Isl1
Detection system: Secondary antibody coupled to Cy5
Results
Specimen 4A/D: embryonic day 10.5; Smad1tm1Abr/Smad1tm1Abr (more )
Note: Double labeled: red - Isl1; green - Lhx2 (assay MGI:6727049) and Lhx9 (assay MGI:6727114).
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present Regionally restricted 4A , 4D Expressed in association (dI3) and motor neurons (MNs).
Specimen 4E/H: embryonic day 10.5; Smad1tm1Abr/Smad1tm1Abr, Tg(Pou3f4-cre)32Cren/0 (more )
Note: Conditional mutant. Double labeled: red - Isl1; green - Lhx2 (assay MGI:6727049) and Lhx9 (assay MGI:6727114).
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present Regionally restricted 4H , 4E Expressed in association (dI3) and motor neurons (MNs), similar as in the control.
Specimen 4I/L: embryonic day 10.5; Smad5tm1Huy/Smad5tm1Huy (more )
Note: Double labeled: red - Isl1; green - Lhx2 (assay MGI:6727049) and Lhx9 (assay MGI:6727114).
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present Regionally restricted 4I , 4L Expressed in association (dI3) and motor neurons (MNs).
Specimen 4M/P: embryonic day 10.5; Smad5tm1Huy/Smad5tm1Huy, Tg(Pou3f4-cre)32Cren/0 (more )
Note: Conditional mutant. Double labeled: red - Isl1; green - Lhx2 (assay MGI:6727049) and Lhx9 (assay MGI:6727114).
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present Regionally restricted 4M , 4P Reduced expression (almost 40%) in association (dI3) neurons, compared with the control. Expression in the motor neurons (MNs) was similar as in the control.
Specimen not shown: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present Regionally restricted Expressed in motor neurons (MNs).
Specimen not shown: embryonic day 10.5; Smad1tm1Abr/Smad1tm1Abr, Smad5tm1Huy/Smad5tm1Huy, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present Regionally restricted Expressed in the motor neurons (MNs), similar as in the control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory