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Gene Expression Data
Assay Details
Assay
Reference: J:288446 Christians A, et al., Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies. Hum Mol Genet. 2020 May 8;29(7):1192-1204
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6472979
Gene symbol: Mki67
Gene name: antigen identified by monoclonal antibody Ki 67
Antibody: anti-Ki67 (TEC-3; M7249)
Detection system: Alexa Fluor 555
Results
Specimen 3D left +/+: embryonic day 18.5 (more )
Note: Double labeled: red - Mki67; green - Krt5 (assay MGI:6472971).
Structure Level Pattern Image Note
TS26: intermediate cell layer of ureter Present 3D left +/+
TS26: superficial cell layer of ureter Present 3D left +/+
TS26: basal cell layer of ureter Present 3D left +/+
Specimen 3D left -/-: embryonic day 18.5; Lifrtm1Imx/Lifrtm1Imx (more )
Note: Double labeled: red - Mki67; green - Krt5 (assay MGI:6472971).
Structure Level Pattern Image Note
TS26: intermediate cell layer of ureter Present 3D left -/- Increased proliferation compared with the wild-type.
TS26: superficial cell layer of ureter Present 3D left -/- Increased proliferation compared with the wild-type.
TS26: basal cell layer of ureter Present 3D left -/- Proliferation was scarcely altered, compared with the wild-type.
Specimen 3D right +/+: embryonic day 18.5 (more )
Note: Double labeled: red - Mki67; green - Trp63 (assay MGI:6472977).
Structure Level Pattern Image Note
TS26: basal cell layer of ureter Present 3D right +/+
TS26: intermediate cell layer of ureter Present 3D right +/+
TS26: superficial cell layer of ureter Present 3D right +/+
Specimen 3D right -/-: embryonic day 18.5; Lifrtm1Imx/Lifrtm1Imx (more )
Note: Double labeled: red - Mki67; green - Trp63 (assay MGI:6472977).
Structure Level Pattern Image Note
TS26: intermediate cell layer of ureter Present 3D right -/- Increased proliferation compared with the wild-type.
TS26: superficial cell layer of ureter Present 3D right -/- Increased proliferation compared with the wild-type.
TS26: basal cell layer of ureter Present 3D right -/- Proliferation was scarcely altered, compared with the wild-type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory