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Gene Expression Data
Assay Details
Assay
Reference: J:148710 Ezhkova E, et al., Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell. 2009 Mar 20;136(6):1122-35
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6450682
Gene symbol: Mki67
Gene name: antigen identified by monoclonal antibody Ki 67
Antibody: anti-Ki67
Results
Specimen 3D WT: postnatal day 0 (more )
Note: Double labeled: red - Mki67; green - Itgb4 (assay MGI:6450681).
Structure Level Pattern Image Note
TS27: epidermis basal layer Present 3D WT
TS27: epidermis suprabasal layer Present 3D WT
Specimen 3D cKO: postnatal day 0; Ezh2tm1Tara/Ezh2tm1Tara, Tg(KRT14-cre)1Efu/0 (more )
Note: Conditional mutant. Double labeled: red - Mki67; green - Itgb4 (assay MGI:6450681).
Structure Level Pattern Image Note
TS27: epidermis Weak 3D cKO Fewer expressing cells in mutant epidermis.
Specimen S1B: embryonic day 14.0 (more )
Note: Double labeled: red - Mki67; green - Itgb4 (assay MGI:6450681).
Structure Level Pattern Image Note
TS22: epidermis Present Regionally restricted S1B Expression in basal layer of progenitors and layer of suprabasal cells at E16.
Specimen S1D: embryonic day 16.0 (more )
Note: Double labeled: red - Mki67; green - Itgb4 (assay MGI:6450681).
Structure Level Pattern Image Note
TS24: epidermis Weak Regionally restricted S1D Proliferation restricted to basal layer. Expression wanes as epidermis matures.
Specimen S1G: postnatal day 9 (more )
Note: Double labeled: red - Mki67; green - Itgb4 (assay MGI:6450681).
Structure Level Pattern Image Note
TS28: hair outer root sheath Present S1G
Specimen S1H: postnatal day 9 (more )
Note: Double labeled: red - Mki67; green - antibody AE15.
Structure Level Pattern Image Note
TS28: hair root sheath matrix Present S1H
Specimen S1K: postnatal day 22 (more )
Note: Double labeled: red - Mki67; green - Krt5 (assay MGI:6450683).
Structure Level Pattern Image Note
TS28: hair outer root sheath Present S1K
TS28: hair root sheath matrix Present S1K
Specimen S1M: postnatal day 22 (more )
Note: Double labeled: red - Mki67; green - Cd34 (assay MGI:6450686).
Structure Level Pattern Image Note
TS28: hair root sheath matrix Present S1M
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory