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Gene Expression Data
Assay Details
Assay
Reference: J:231312 Baardman ME, et al., Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development. Dis Model Mech. 2016 Apr 1;9(4):413-25
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6444467
Gene symbol: Lrp2
Gene name: low density lipoprotein receptor-related protein 2
Antibody: anti-Lrp2
Detection system: Secondary antibody coupled to Alexa Fluor 555
Results
Specimen 2A: embryonic day 10.5 (more )
Note: Double labeled: red - Lrp2; green - Nkx2-5 (assay MGI:6444460).
Structure Level Pattern Image Note
TS17: heart mesenchyme Present Regionally restricted 2A Expressed in the mesenchyme surrounding the non-septated cardiac outflow tract region. Mainly in the non-myocardial cells (Nkx2.5-negative cells).
Specimen 2B: embryonic day 11.5 (more )
Note: Double labeled: red - Lrp2; green - Nkx2-5 (assay MGI:6444460).
Structure Level Pattern Image Note
TS19: ascending aorta Present 2B
TS19: parietal pericardium Present 2B
TS19: pulmonary trunk Present 2B
TS19: heart mesenchyme Present Regionally restricted 2B Expressed in the mesenchyme surrounding the non-septated cardiac outflow tract region. Mainly in the non-myocardial cells (Nkx2.5-negative cells).
TS19: cardiac muscle tissue Absent 2B
TS19: visceral pericardium Absent 2B
Specimen 2C: embryonic day 12.5 (more )
Note: Double labeled: red - Lrp2; green - Nkx2-5 (assay MGI:6444460).
Structure Level Pattern Image Note
TS20: ascending aorta Present 2C
TS20: parietal pericardium Present 2C
TS20: pulmonary trunk Present 2C
TS20: heart mesenchyme Present Regionally restricted 2C Expressed in the mesenchyme in the cardiac outflow tract cushions. Mainly in the non-myocardial cells (Nkx2.5-negative cells).
TS20: endocardial lining Weak 2C
TS20: visceral pericardium Weak 2C
Specimen 2D: embryonic day 13.5 (more )
Note: Double labeled: red - Lrp2; green - Nkx2-5 (assay MGI:6444460).
Structure Level Pattern Image Note
TS21: outflow tract Present Regionally restricted 2D Expressed in the developing intercalated cushions.
TS21: visceral pericardium Absent 2D
TS21: endocardial lining Strong Regionally restricted 2D Expressed in the outflow tract region.
TS21: heart mesenchyme Present Regionally restricted 2D Expressed in the mesenchyme in the cardiac outflow tract cushions. Mainly in the non-myocardial cells (Nkx2.5-negative cells).
TS21: parietal pericardium Present 2D
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory