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Gene Expression Data
Assay Details
Assay
Reference: J:229352 Metzger DE, et al., Grg3/TLE3 and Grg1/TLE1 induce monohormonal pancreatic beta-cells while repressing alpha-cell functions. Diabetes. 2014 May;63(5):1804-16
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6441170
Gene symbol: Gcg
Gene name: glucagon
Antibody: anti-glucagon
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 1A: embryonic day 17.5 (more )
Note: Triple labeled: gray - Gcg; green - Tle3 (assay MGI:6441177); red - Ins1 (assay MGI:6441181) and Ins2 (assay MGI:6441475).
Structure Level Pattern Image Note
TS25: pancreas Present 1A right , 1A left Many Gcg-positive alpha-cells were Tle3 negative or had low-level nuclear Tle3 expression.
Specimen 1B right: postnatal adult (more )
Note: Double labeled: gray - Gcg; green - Tle3 (assay MGI:6441177).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present 1B right The majority of Gcg-positive alpha-cells were Tle3 negative. The percentage of Tle3+ alpha-cells decreased from E17.5 (47%) to the adult (14%).
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
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