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Gene Expression Data
Assay Details
Assay
Reference: J:287484 Tomita H, et al., The Protein Tyrosine Phosphatase Receptor Delta Regulates Developmental Neurogenesis. Cell Rep. 2020 Jan 7;30(1):215-228.e5
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6437932
Gene symbol: Tbr1
Gene name: T-box brain transcription factor 1
Antibody: anti-Tbr1 (AB31940)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Assay notes: Another Ptprd knockout allele (Ptprd<tm2a(KOMP)Wtsi>) was mentioned in the paper. It was not specified which allele was used.
Results
Specimen 5G WT: postnatal day 7 (more )
Note: Quantified in Fig 5H/I.
Structure Level Pattern Image Note
TS28: cerebral cortex Present 5G left Expressed in cortical neurons.
Specimen 5G KO: postnatal day 7; Ptprdtm1Yiw/Ptprdtm1Yiw (more )
Note: Quantified in Fig 5H/I.
Structure Level Pattern Image Note
TS28: cerebral cortex Present 5G right Significantly increased numbers of the positive cortical neurons, compared with the wild-type.
TS28: cortical layer I Present 5G right Significantly increased proportion of total positive neurons relative to the wild-type.
TS28: cortical layer II Present 5G right Significantly increased proportion of total positive neurons relative to the wild-type.
TS28: cortical layer III Present 5G right Significantly increased proportion of total positive neurons relative to the wild-type.
TS28: cortical layer IV Present 5G right Significantly increased proportion of total positive neurons relative to the wild-type.
TS28: cortical layer V Present 5G right Significantly decreased proportion of total positive neurons relative to the wild-type.
TS28: cortical layer VI Present 5G right Significantly decreased proportion of total positive neurons relative to the wild-type.
Specimen not shown: postnatal day 7; Ptprdtm1Yiw/Ptprd+ (more )
Note: Quantified in Fig 5H/I.
Structure Level Pattern Image Note
TS28: cerebral cortex Present Significantly increased numbers of the positive cortical neurons, compared with the wild-type.
TS28: cortical layer V Present Significantly decreased proportion of total positive neurons relative to the wild-type.
TS28: cortical layer VI Present Significantly decreased proportion of total positive neurons relative to the wild-type.
TS28: cortical layer I Present Significantly increased proportion of total positive neurons relative to the wild-type.
TS28: cortical layer II Present Significantly increased proportion of total positive neurons relative to the wild-type.
TS28: cortical layer III Present Significantly increased proportion of total positive neurons relative to the wild-type.
TS28: cortical layer IV Present Significantly increased proportion of total positive neurons relative to the wild-type.
Specimen S3C: postnatal day 7 (more )
Note: Double labeled: green - Tbr1; red - Satb2 (assay MGI:6437931).
Structure Level Pattern Image Note
TS28: cerebral cortex Present S3C merge , S3C left Expressed in cortical neurons.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory